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EC number: 205-087-0
CAS number: 133-06-2
The potential of captan to
induce chromosomal damage was investigated by the micronucleus test. The
procedures used complied with the recommendations of the OECD Guideline
for Testing of Chemicals No. 474.
Charles River CD-I mice were
orally administered captan suspended in 0.5% carboxymethyl cellulose
(CMC) at dosages of 40, 200 and 1000 mg/kg at a constant volume-dosage
of 10 ml/kg on Day 1. Dosages were selected on the basis of a
preliminary toxicity test.
There was no increase in the
frequency of micronucleated polychromatic cells in captan-treated
groups, and no alteration in the ratio of polychromatic to
nonnochromatic cells was apparent.
Chlorambucil, a known
mutagen, used as a positive control, caused a significant increase in
the frequency of micronucleated cells.
The test material, captan,
was devoid of mutagenic activity under the conditions of this study.
The result is in accordance
with several other in vivo tests on captan (e.g. Tezuka, H.).
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