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EC number: 205-087-0
CAS number: 133-06-2
Clinical findings: There were no mortalities. All animals appeared
normal throughout the observation period, except two rabbits which had
wet areas around the eyes on days 4 and 5.
Local findings: There were no signs of dermal irritation.
Autopsy: No abnormalities were observed at necropsy.
A single dose of captan was applied to the closely clipped abdominal
skin of male and female Stauffland albino rabbits at a dose of 2000
mg/kg bw (5 animals/sex). The skin was abraded on half of the animals
and left intact on the others. The area was covered with a protective
binder. The binder and test material was removed after 24 hours, the
area inspected and rewrapped in a gauze binder. After three days, the
gauze binder was removed. A concurrent control (2 animals/sex) was also
conducted. All animals were observed for clinical signs for at least 14
days after treatment and were necropsied at the end of the observation
Captan was in this study of low toxicity via dermal route of exposure.
Based on this study captan is not classified to be acute toxic for
dermal exposure. Nevertheless positive results for sensitisation
(Dreher, D.M. 1991) have to be considered leading to classification as
skin sensitizing cat. 1 (H317).
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