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EC number: 205-087-0 | CAS number: 133-06-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicity to terrestrial arthropods
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to terrestrial arthropods: short-term
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19 July to 3 August 1990
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Remarks:
- GLP - Guideline study The experiments were done according to the UK MAFF PSPS Working Document D3 (1979).
- Qualifier:
- according to guideline
- Guideline:
- other: UK MAFF PSPS Working Document D3 (1979)
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method C.16 (Honeybees - Acute Oral Toxicity Test)
- GLP compliance:
- yes
- Application method:
- other: contact and oral
- Analytical monitoring:
- no
- Vehicle:
- yes
- Remarks:
- acetone
- Test organisms (species):
- Apis mellifera
- Animal group:
- Hymenoptera (honeybees)
- Study type:
- laboratory study
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Test temperature:
- 22.5 - 24° C
- Humidity:
- 56 - 68% relative humidity
- Key result
- Duration:
- 24 h
- Dose descriptor:
- LD50
- Effect conc.:
- > 100 µg per animal
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks:
- oral
- Remarks on result:
- other: 0.154 - 0.218 % CL
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LD50
- Effect conc.:
- > 100 µg per animal
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks:
- oral
- Remarks on result:
- other: 0.142 - 0.206 % CL
- Key result
- Duration:
- 24 h
- Dose descriptor:
- other: NOEL
- Effect conc.:
- >= 100 µg per animal
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks:
- oral
- Key result
- Duration:
- 48 h
- Dose descriptor:
- other: NOEL
- Effect conc.:
- >= 100 µg per animal
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks:
- oral
- Key result
- Duration:
- 24 h
- Dose descriptor:
- LD50
- Effect conc.:
- > 200 µg per animal
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks:
- contact
- Remarks on result:
- other: 0.166 - 0.215 % CL
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LD50
- Effect conc.:
- > 200 µg per animal
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks:
- contact
- Remarks on result:
- other: 0.150 - 0.199 % CL
- Key result
- Duration:
- 24 h
- Dose descriptor:
- other: NOEL
- Effect conc.:
- >= 200 µg per animal
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks:
- contact
- Key result
- Duration:
- 48 h
- Dose descriptor:
- other: NOEL
- Effect conc.:
- >= 200 µg per animal
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks:
- contact
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The 24 and 48-hour oral LD50 of captan to the honey bee is higher than 100 µg captan/bee. The 24 and 48-hour contact LD50 of captan to the honey bee is higher than 200 µg captan/bee.
- Executive summary:
Laboratory tests was carried out on captan technical. There were two tests for each route of administration for technical captan: a rangefinder test and a definitive test based on the results of the rangefinder test.
The 24 hour contact LD50 values for technical captan was >200 and >20 µg bee-1, respectively. The 24-hour oral LD50 values for technical captan was >100 and >20 µg bee-1. The No Observed Effect Levels (NOELs) were greater than, or equal to, the highest dose tested in each case. Results obtained for dimethoate tested concurrently as a toxic standard indicated that the bees were reacting normally under the test conditions
Reference
Contact Tests
The 20 µg bee-1dose level of the formulation required the application of two 1 µL drops. Therefore this treatment was not strictly comparable with the others which received 1 µL. Consequently, it was excluded from the statistical analysis. This had no effect on the conclusions reached as to the LD50 value or the NOEL because of the total lack of observed effects on bees in this treatment.
There was no mortality attributable to technical captan so that the 24- hour LD50s were greater than the highest dose tested: 200 and 20 µg bee-1, respectively. The 48- hour results were similar.
There were no treatment related sublethal effects observed in bees treated with technical captan. Using the combined mortality and sub-lethal effects values, the NOELs were therefore equal to or greater than the highest dose tested (200 and 20 µg bee-1, respectively).
Oral Tests
There was no mortality or sublethal effects attributable to either technical Captan. Therefore, the 24- and 48- hour LD50 values were greater than and the NOELs equal to or greater than the highest doses tested: 100 µg bee-1for technical captan.
Overall there were no treatment-related mortalities or sublethal effects of captan in the oral or contact
tests at any dose at any assessment time. Mortality following treatment with dimethoate occurred at expected levels.
Description of key information
Toxicity to terrestrial arthropods: LD50 (oral, 24h and 48h) >100 µg captan/bee, LD50 (contact, 24h and 48h) >200 µg captan/bee for worker Honey bees (Apis mellifera), Guideline UK MAFF PSPS Working Document D3 (1979).
Toxicity to terrestrial arthropods: LD50 (oral, 24h and 48h) >100 µg captan/bee,
LD50 (contact, 24h and 48h) >200 µg captan/bee for worker Honey bees (Apis mellifera), Guideline UK MAFF PSPS Working Document D3 (1979).
Key value for chemical safety assessment
Additional information
The result show that the 24-hour contact LD50 values for technical captan was >200 and >20 µg bee-1, respectively. These results indicate that the technical material is 'virtually non-toxic' to bees in the laboratory under the conditions of these tests (using the classification of the International Commission for Bee Botany-Second Symposium on harmonisation of methods for testing the toxicity of pesticides to bees, Hohenheim, West Germany, 21-23 September 1982). There were no treatment effects at the doses tested there is no evidence of any difference in the level of safety. There were no treatment related sublethal effects for the technical material so that the NOEL were ≥200 and ≥20 µg ai bee-1,respectively. There were no significant changes in the results in either the contact or the oral tests after 48 hours compared with 24 hours indicating that there were no delayed effects.
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