Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-087-0
CAS number: 133-06-2
The individual scores for erythema/eschar and oedema, are given in Table 7.3.1 -1. Very slight erythema was noted at all treated skin sites one and 24 hours after patch removal and at one treated skin site at the 48-hour observation. All treated skin sites appeared normal 72 hours after treatment.
Table 7.3.1 -1 Dermal irritation responses in rabbits: individual dermal responses
Draize grade after
Overall average means1
O = oedema.
E = erythema and eschar formation.
1Mean for individual animals over three time points 24, 48 and 72 hours
for each lesion, calculated as mean score at (24 hours + 48 hours + 72 hours)/3.
A study was performed to assess the irritancy potential of the test
material to the skin of the New Zealand White rabbit. The method used
followed that described in the OECD Guidelines for Testing of Chemicals
(1981) No. 404 "Acute Dermal Irritation/Corrosion" referenced as EU
method B.4 published in the regulation 440/2008.
A single 4-hour, semi-occluded application of the test material to the
intact skin of three rabbits produced very slight erythema. All treated
skin sites appeared normal 72 hours after treatment.
The test material produced a primary irritation index of 0.5 and was
classified as a mild irritant to rabbit skin according to the Draize classification
scheme. No corrosive effects were noted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Sellel veebilehel kasutatakse küpsiseid, et tagada lehe parim kasutus.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again