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EC number: 205-087-0
CAS number: 133-06-2
Analysis of solutions: Mean measured concentrations of captan in the solvent stock solutions ranged from 82 to 100% of the nominal values based on calculated values from each respective solvent stock solution. The results are, therefore, presented as nominal values. The physical and chemical parameters of the test solutions remained at expected values during the study (pH 7.3 to 8.1 for all treatments).
Toxicity and behaviour: No treatment-related symptoms of toxicity apart from mortality were observed. There was no treatment-related effect on fish weight or length. The results are summarised in Table 6.1.2 -1.
Table 6.1.2-1 Summary of effects of captan on rainbow trout following 21-day exposure
Mean fish weight (g)
Mean fish length
TD = test terminated.
The 21 day LC50 of captan to rainbow trout (Salmo gairdneri) was determined in freshwater. A dynamic (flowthrough) system was used to determine the 4.7,10,14 and 21 day LC50 values. Rainbow trout (Salmo gairdneri, also known as Oncorhynchus mykiss) a freshwater species, was selected as the test organism.
The bioassay test method used in this study was based on OECD Guideline Number 204. The nominal test exposure concentrations used in this study were 100, 56, 32, 18, 10 and 5.6 µg of captan technical per litre, together with a dilution water and solvent control. Each test concentration was run unreplicated without aeration. The anlyses to determine the levels of captan technical were done by high performance liquid chromatographic method. Samples of all new stock solutions were analysed to confirm nominal values.
Observations of mortalities and symptoms of toxicity were made daily. Mortalities were recorded daily and symptoms of toxicity were recorded on days 4,7,10, 14 and 21. The LC50 value was calculated at various time intervals by the ICI Group Environmental Laboratory computer program "LC50" using Stephan´s method. The results were calculated by using the moving average angle method.
The general symptoms of toxicity noted in this study were quiescence, weakness, loss of balance, dark discolouration and slow respiration. However, these symptoms were exhibited by only a single fish in the nominal 32 µg/L exposure concentration and were considered not to be dose related.
The LC50 values and 95% confidence intervals are shown below as µg of captan technical per litre based on nominal concentrations. Calculation method: Moving average angle
Time: 4 day, LC50: 75 µg/L, 95% confidence interval: 63- 96
Time: 7 day, LC50: 75 µg/L, 95% confidence interval: 63- 96
Time: 10 day, LC50: 75 µg/L, 95% confidence interval: 63- 96
Time: 14 day, LC50: 75 µg/L, 95% confidence interval: 61- 100
Time: 21 day, LC50: 75 µg/L, 95% confidence interval: 61- 100
There were no mortalities attributable to captan technical in the dilution water and solvent controls or in the nominal concentrations of 56 µg/L or less during the 21 day exposure. The single mortalities in the nominal exposure concentrations of 32 and 5.6 µg/L were considered to have been random and not due to any effect of captan.
The no observed effect concentration (NOEC) of captan (based on mortalities and symptoms of toxicity) was therefore determined to be 56 µg/L on the basis of nominal concentrations. The threshold level of both lethal and observed effect was determined at 100 µg/L (nominal concentration). The lowest nominal concentration at which there was 100% mortality was 100 µg/L.
Longterm toxicity to fish (rainbow trout): LC50 (21 day) = 75 µg/l, NOEC (21 day, mortality) = 56 µg/l, OECD 204.
Long-term toxicity to fish was determined according to OECD 204. For rainbow trout under flow-through conditions LC50 (21 day) = 75 µg/l and NOEC (21 day, mortality) = 56 µg/l were found. Increased exposure time (21 days) for rainbow trout did not increase toxicity (21-day LC50 = 0.075 mg/L) compared to the acute value (96-hour LC50 = 0.056 mg/L), under flow-through test conditions.
According to regulation 1272/2008 captan is classified as acute toxic in aquatic systems category 1 (H400).
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