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EC number: 205-087-0
CAS number: 133-06-2
Table 7.2.2-02 Acute inhalation toxicity of captan in rats: summary of toxicity
Duration of signs2
Time of death3
0.23 ± 0.04
during exposure - 5 d4
(0.43 - 1.90)
0.94 ± 0.05
during exposure - 7 d4
4.81 ± 0.36
23 ± 0.04
during exposure - 4 d4
(0.36 - 1.22)
1 h - 2 d4
1Mean ± sd.
2Number of animals which died/number of animals with clinical signs/number of animals in dose group.
3Day number of test.
5Deaths occurred during exposure or immediately following removal from test chamber at 4 hours.
A study was performed to
assess the acute Inhalation toxicity of the test material, as supplied,
by exposing groups of ten Sprague-Dawley strain rats (five males and
five females) to various concentrations of a dust atmosphere. The
animals were exposed for up to four hours using a nose only exposure
The method applied was
according to OECD Guidelines No. 403 (1981)
During exposure signs of wet
fur and decreased respiratory rate were noted. On removal from the
chamber common signs of toxicity noted were hunched posture, lethargy,
pllo-erection, ataxia and ptosis. Incidents of gasping, laboured and
noisy respiration and red/brown stains around the snout were apparent.
Isolated Incidents of pallor of the extremities, dehydration and
frequent sneezing were also noted. Surviving animals treated with 0.94
mg/litre appeared normal on day seven and those treated with 0.23
mg/litre appeared normal four to five days following exposure
During week one following
exposure to 0.94 mg/litre one surviving animal showed normal bodyweight
gain and two showed bodyweight loss. Normal bodyweight gain was noted
during week two. Expected bodyweight gain was noted in all animals
exposed to 0.23 mg/litre throughout the study.
Common abnormalities noted
at necropsy were haemorrhage and swollen appearance of the lungs and
presence of fluid in the lungs. All animals exposed to 4,81 mg/litre and
two exposed to 0.94 mg/litre showed reddened or congested small
intestines. There were two incidents of fluid present in the nasal/oral
tract in animals exposed to 0.94 mg/litre.
Isolated incidents of pale
lungs, fluid present in the lung cavity, patchy pallor of the liver,
dark liver and haemorrhage in the small Intestine were also noted. Three
surviving animals exposed to 0.94 mg/litre and all animals exposed to
0.23 mg/litre showed no abnormalities.
The acute inhalation median
lethal concentration (LC50) and 9S% confidence limits of the test
material CAPTAN TECHNICAL, in the Sprague-Dawley strain rat, were
calculated to be:
All animals: 0.78 (0.49 -
Males only: 0.90 (0.43 -
Females only: 0.67 (0.36 -
In consquence captan has to
be classified as acute toxic cat. 3 (H331) according to Eu regulation
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