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EC number: 205-087-0
CAS number: 133-06-2
1. Acute (one single dose) study oral (gavage), rat m/f, (OECD 401 (1987) = EEC B.1 (1992): LD50 > 2000 mg/kg bodyweight.
2. Acute (single 4 hour exposure) study inhalation, rat m/f, EEC B.2 (1984), OECD 403 (1984): LC50 = 0.67 mg/l (female, 95% confidence limits 0.36 - 1.22).In accordance with the provisions of regulation 1272/2008, Annex I, 3. is classified as acute toxic cat. 3 .
3. Acute (one single application) study dermal, rabbit m/f, EPA FIFRA, Subdivision F, §81-2 (1981) = EEC B.3 (1992): LD50 > 2000 mg/kg
The study was performed to assess the acute oral toxicity of captan in
the Sprague-Dawley strain rat. The method used followed OECD Guidelines
No. 401 "Acute Oral Toxicity" referenced as Method B1 in the regulation
440/2008. Following a range-finding study, a group of ten fasted animals
(five males and five females) was given a single oral dose of test
material, as a suspension in distilled water at a dose level of 2000
The animals were observed for fourteen days after the day of dosing and
were then killed for gross pathological examination.
There were no deaths. No signs of systemic toxicity were noted during
the study. All animals showed expected gain in bodyweight during the
study. No abnormalities were noted at necropsy. The acute oral median
lethal dose (LD50) of the test material in the Sprague-Dawley strain rat
was found to be higher than 2000 mg/kg bodyweight.
Table 7.2.2-02 Acute inhalation toxicity of captan in rats: summary of toxicity
Duration of signs2
Time of death3
0.23 ± 0.04
during exposure - 5 d4
(0.43 - 1.90)
0.94 ± 0.05
during exposure - 7 d4
4.81 ± 0.36
23 ± 0.04
during exposure - 4 d4
(0.36 - 1.22)
1 h - 2 d4
1Mean ± sd.
2Number of animals which died/number of animals with clinical signs/number of animals in dose group.
3Day number of test.
5Deaths occurred during exposure or immediately following removal from test chamber at 4 hours.
A study was performed to
assess the acute Inhalation toxicity of the test material, as supplied,
by exposing groups of ten Sprague-Dawley strain rats (five males and
five females) to various concentrations of a dust atmosphere. The
animals were exposed for up to four hours using a nose only exposure
The method applied was
according to OECD Guidelines No. 403 (1981)
During exposure signs of wet
fur and decreased respiratory rate were noted. On removal from the
chamber common signs of toxicity noted were hunched posture, lethargy,
pllo-erection, ataxia and ptosis. Incidents of gasping, laboured and
noisy respiration and red/brown stains around the snout were apparent.
Isolated Incidents of pallor of the extremities, dehydration and
frequent sneezing were also noted. Surviving animals treated with 0.94
mg/litre appeared normal on day seven and those treated with 0.23
mg/litre appeared normal four to five days following exposure
During week one following
exposure to 0.94 mg/litre one surviving animal showed normal bodyweight
gain and two showed bodyweight loss. Normal bodyweight gain was noted
during week two. Expected bodyweight gain was noted in all animals
exposed to 0.23 mg/litre throughout the study.
Common abnormalities noted
at necropsy were haemorrhage and swollen appearance of the lungs and
presence of fluid in the lungs. All animals exposed to 4,81 mg/litre and
two exposed to 0.94 mg/litre showed reddened or congested small
intestines. There were two incidents of fluid present in the nasal/oral
tract in animals exposed to 0.94 mg/litre.
Isolated incidents of pale
lungs, fluid present in the lung cavity, patchy pallor of the liver,
dark liver and haemorrhage in the small Intestine were also noted. Three
surviving animals exposed to 0.94 mg/litre and all animals exposed to
0.23 mg/litre showed no abnormalities.
The acute inhalation median
lethal concentration (LC50) and 9S% confidence limits of the test
material CAPTAN TECHNICAL, in the Sprague-Dawley strain rat, were
calculated to be:
All animals: 0.78 (0.49 -
Males only: 0.90 (0.43 -
Females only: 0.67 (0.36 -
In consquence captan has to
be classified as acute toxic cat. 3 (H331) according to Eu regulation
Clinical findings: There were no mortalities. All animals appeared
normal throughout the observation period, except two rabbits which had
wet areas around the eyes on days 4 and 5.
Local findings: There were no signs of dermal irritation.
Autopsy: No abnormalities were observed at necropsy.
A single dose of captan was applied to the closely clipped abdominal
skin of male and female Stauffland albino rabbits at a dose of 2000
mg/kg bw (5 animals/sex). The skin was abraded on half of the animals
and left intact on the others. The area was covered with a protective
binder. The binder and test material was removed after 24 hours, the
area inspected and rewrapped in a gauze binder. After three days, the
gauze binder was removed. A concurrent control (2 animals/sex) was also
conducted. All animals were observed for clinical signs for at least 14
days after treatment and were necropsied at the end of the observation
Captan was in this study of low toxicity via dermal route of exposure.
Based on this study captan is not classified to be acute toxic for
dermal exposure. Nevertheless positive results for sensitisation
(Dreher, D.M. 1991) have to be considered leading to classification as
skin sensitizing cat. 1 (H317).
For oral application of 2000 mg/kg bw captan to rats no mortalities were observed. All animals showed expected gain in bodyweight during the study but no abnormalities were noted at necropsy.
For inhalation exposure with captan all animals treated showed clinical signs during exposure (e.g. wet fur, decreased respiratory rate) and after exposure (e.g. hunched posture, lethargy, pilo-erection, ataxia, ptosis). LC 50 value was determined 0.67 mg/l. Due to inhalation toxicity captan has to be classified as acute toxic for inhalation cat. 3.
For dermal application of 2000 mg/kg bw captan to albino rabbits no mortalities were noted. All animals appeared normal throughout the observation period, except two rabbits which had wet areas around the eyes on days 4 and 5. There were no signs of dermal irritation and no abnormalities were observed at necropsy.
According to EU regulation 1272/2008 captan is neither toxic for dermal nor for oral exposure as classification thresholds (Annex I, chapter 3.1) were not reached. For inhalation exposure an LC50 value of 670 mg/m3 was determined, leading to classification as acute toxic category 3 by inhalation.
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