Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information


Currently viewing:

Administrative data

Description of key information

1 -chloro-2 -nitrobenzene has a carcinogenic potential.

Key value for chemical safety assessment

Justification for classification or non-classification


DSD: Category 3, Xn, R40 Limited evidence of a carcinogenic effect

EU-GHS: Category 2 carcinogen

Additional information

In two studies the cancer potential of 1 -chloro-2 -nitrobenzene was investigated in rats and mice (Weisburger et al., 1978 and Matsumoto et al., 2006).

Multiple tumours at the low dose were observed in rats (no dose-response) and liver tumours in mice (Weisburger et al., 1978). A pituitary adenoma along with either a stomach papilloma, adrenal tumour, thyroid adenocarcinoma, lymphosarcoma, choliangosarcoma of the liver or subcutaneous fibroma was observed (incidences: low dose level:7/22, high dose level:1/19, simultaneous control: 1/22, pooled control: 14/111).

In the second study hepatic tumours in rats and mice were reported (Matsumoto et al., 2006).

There is evidence that 1 -chloro-2 -nitrobenzene has a carcinogenic potential.