Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-854-9 | CAS number: 88-73-3
Carcinogenicity
Administrative data
Description of key information
1 -chloro-2 -nitrobenzene has a carcinogenic potential.
Key value for chemical safety assessment
Justification for classification or non-classification
Classification:
DSD: Category 3, Xn, R40 Limited evidence of a carcinogenic effect
EU-GHS: Category 2 carcinogen
Additional information
In two studies the cancer potential of 1 -chloro-2 -nitrobenzene was investigated in rats and mice (Weisburger et al., 1978 and Matsumoto et al., 2006).
Multiple tumours at the low dose were observed in rats (no dose-response) and liver tumours in mice (Weisburger et al., 1978). A pituitary adenoma along with either a stomach papilloma, adrenal tumour, thyroid adenocarcinoma, lymphosarcoma, choliangosarcoma of the liver or subcutaneous fibroma was observed (incidences: low dose level:7/22, high dose level:1/19, simultaneous control: 1/22, pooled control: 14/111).
In the second study hepatic tumours in rats and mice were reported (Matsumoto et al., 2006).
There is evidence that 1 -chloro-2 -nitrobenzene has a carcinogenic potential.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
