Registration Dossier
Registration Dossier
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EC number: 201-854-9 | CAS number: 88-73-3
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented publication/study report which meets basic scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Deviations:
- not applicable
- Principles of method if other than guideline:
- Method: 3 drops(10% sol.) to the clipped area of the skin; 22nd d inj.of Freund-adjuvans and TS into the hind paw (0.5 mg/kg bw), 28th d 3 drops (10 % sol.) to an untreated clipped area of the skin; reading time not mentioned
- GLP compliance:
- no
- Type of study:
- other: modified Freunds complete adjuvant test
Test material
- Reference substance name:
- 1-chloro-2-nitrobenzene
- EC Number:
- 201-854-9
- EC Name:
- 1-chloro-2-nitrobenzene
- Cas Number:
- 88-73-3
- Molecular formula:
- C6H4ClNO2
- IUPAC Name:
- 1-chloro-2-nitrobenzene
- Details on test material:
- - Name of test material (as cited in study report): Ortho-nitrochlorbenzol
- Analytical purity: no data
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- other: epicutaneous, no more informations
- Vehicle:
- other: acetone
- Concentration / amount:
- 10% in acetone
Challengeopen allclose all
- Route:
- other: epicutaneous, no more informations
- Vehicle:
- other: acetone
- Concentration / amount:
- 10% in acetone
- No. of animals per dose:
- 10
- Details on study design:
- 1st application: Induction 10 % ; 2nd application: Challenge 10 %
- Challenge controls:
- no data
- Positive control substance(s):
- not specified
Study design: in vivo (LLNA)
- Statistics:
- no data
Results and discussion
Any other information on results incl. tables
No more data given
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information
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