Registration Dossier
Registration Dossier
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EC number: 201-854-9 | CAS number: 88-73-3
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: migrated IUCLID4 data set
Data source
Reference
- Reference Type:
- publication
- Title:
- Biochem. J. 64, 38-44
- Author:
- Bray, H.G. et al.
- Year:
- 1 956
Materials and methods
Test material
- Reference substance name:
- 1-chloro-2-nitrobenzene
- EC Number:
- 201-854-9
- EC Name:
- 1-chloro-2-nitrobenzene
- Cas Number:
- 88-73-3
- Molecular formula:
- C6H4ClNO2
- IUPAC Name:
- 1-chloro-2-nitrobenzene
Constituent 1
Results and discussion
Metabolite characterisation studies
- Metabolites identified:
- yes
Any other information on results incl. tables
48 h after a single oral administration of 100 mg/kg bw of o-chloronitrobenzene to rabbits,
0.3 % of the administered dose was found in faeces as unabsorbed material which was completely reduced to the chloroaniline;
in the urines collected each 24 h for 48 h the following metabolites of
o-chloronitrobenzene were detectable (expressed as per-
centages of the administered dose):
- ether glucuronide (42 %)
- ethereal sulphate (24 %)
- mercapturic acid (7 %)
- free chloroaniline (9 %)
(total accounted for: 82 %)
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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