Registration Dossier
Registration Dossier
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EC number: 201-854-9 | CAS number: 88-73-3
Toxicity to microorganisms
Administrative data
- Endpoint:
- toxicity to microorganisms
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Standardized procedure. Basic data given.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- QSAR study of the toxicity of nitrobenzene derivatives towards Daphnia magna, Chlorella pyrenoidosa and Photobacterium phosphoreum.
- Author:
- Deneer JW, van Leeuwen CJ, Seinen W, Maas-Diepeveen JL, Hermens JLM
- Year:
- 1 989
- Bibliographic source:
- Aquatic Toxicology 15: 83-98
- Reference Type:
- other: operating manual
- Title:
- Microtox system operating manual 015555879.
- Author:
- Beckman Instruments Inc.
- Year:
- 1 982
- Bibliographic source:
- Beckman Instruments Inc., Carlsbad
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
Materials and methods
- Principles of method if other than guideline:
- Microtox test: carried out as described in the Beckman Instruments Manual (1982)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1-chloro-2-nitrobenzene
- EC Number:
- 201-854-9
- EC Name:
- 1-chloro-2-nitrobenzene
- Cas Number:
- 88-73-3
- Molecular formula:
- C6H4ClNO2
- IUPAC Name:
- 1-chloro-2-nitrobenzene
- Details on test material:
- - Name of test material (as cited in study report): 2-Chloronitrobenzene
- Analytical purity: no data
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test organisms
- Test organisms (species):
- Photobacterium phosphoreum
Study design
- Limit test:
- no
- Total exposure duration:
- 15 min
Test conditions
- Nominal and measured concentrations:
- spacing factor of nominal test substance concentrations: 3.2
Results and discussion
Effect concentrations
- Duration:
- 15 min
- Dose descriptor:
- EC50
- Effect conc.:
- 4.54 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: reduction of bioluminescence
Any other information on results incl. tables
result reported as log EC50 = 1.46 µmol/l
Applicant's summary and conclusion
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