1-chloro-2-nitrobenzene

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Basic data given: comparable to guideline. Adopted according to OECD SIDS. The original source is available and has been reviewed.

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Quantitative Structure-Activity Relationships of Nitroaromatic Compounds to Four Aquatic Organisms.

Author:

Zhao Y-H, Yuan X, Ji G-D, Sheng L-X, Wang L-S

Year:

1997

Bibliographic source:

Chemosphere 34 (8): 1837 - 1844

Reference 2

Reference Type:

secondary source

Title:

1-Chloro-2-nitrobenzene CAS: 88-73-3, SIDS Initial Assessment Report

Author:

OECD

Year:

2001

Bibliographic source:

UNEP publications

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)

Version / remarks:

(1984)

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

1-chloro-2-nitrobenzene

EC Number:

201-854-9

EC Name:

1-chloro-2-nitrobenzene

Cas Number:

88-73-3

Molecular formula:

C6H4ClNO2

IUPAC Name:

1-chloro-2-nitrobenzene

Details on test material:

- Name of test material (as cited in study report): 2-Chloronitrobenzene
- Analytical purity: no data

Sampling and analysis

Analytical monitoring:

not specified

Test organisms

Test organisms (species):

other: Daphnia carinata

Details on test organisms:

TEST ORGANISM
- Age at study initiation: 6-24 hours
- Feeding during test: no

CULTURE
- Temperature: 22 ± 1 °C
- Type and amount of food: green alga
- Photoperiod: 14 h daylight / 10 h darkness

Study design

Test type:

static

Water media type:

freshwater

Total exposure duration:

48 h

Test conditions

Nominal and measured concentrations:

- from information given in publication it can be concluded that 6 concentrations were tested
- publication says: 10 daphnides in 25 mL of test water; the test used 60 daphnides

Details on test conditions:

similar to OECD 202

Results and discussion

Effect concentrations

Duration:

48 h

Dose descriptor:

IC50

Effect conc.:

21.3 mg/L

Nominal / measured:

not specified

Conc. based on:

test mat.

Basis for effect:

mobility

Any other information on results incl. tables

result reported as log1/IC50 = 3.87 mol/L

Applicant's summary and conclusion

Executive summary:

Zhao et al. (1997):

In a toxicity test similar to OECD TG 202 an IC50 of 21.3 mg/L was found for Daphnia carinata after an exposure period of 48 h. This is the most critical, valid value reported for daphnides.