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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
respiratory sensitisation: in vivo
Type of information:
experimental study
Adequacy of study:
other information
Study period:
1973
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Significant methodological deficiencies no data on purity, study documentation incomplete, no data on GLP

Data source

Reference
Reference Type:
publication
Title:
Experimentelle Untersuchungen der allergenen Wirkung von Ortho- und Paranitrochlorbenzol
Author:
Rusakov, N.V. et al.
Year:
1973
Bibliographic source:
Gig. Sanit. No. 3, 13-16 (1973)

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Rats were exposed via inhalation to o-chloronitrobenzene for 5 months.
Vanier and Praustnitz-Küstner method

Test material

Constituent 1
Chemical structure
Reference substance name:
1-chloro-2-nitrobenzene
EC Number:
201-854-9
EC Name:
1-chloro-2-nitrobenzene
Cas Number:
88-73-3
Molecular formula:
C6H4ClNO2
IUPAC Name:
1-chloro-2-nitrobenzene
Details on test material:
- Name of test material (as cited in study report): Ortho-nitrochlorbenzol
- Analytical purity: no data

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Test system

Route of induction exposure:
inhalation
Route of challenge exposure:
other: Vanier and Praustnitz-Küstner method
Vehicle:
other: Vanier and Praustnitz-Küstner method
Concentration:
0, 0,008 mg/m3
No. of animals per dose:
25
Challenge controls:
no data
Positive control substance(s):
none

Results and discussion

Applicant's summary and conclusion

Interpretation of results:
sensitising