Registration Dossier
Registration Dossier
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EC number: 201-854-9 | CAS number: 88-73-3
Respiratory sensitisation
Administrative data
- Endpoint:
- respiratory sensitisation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1973
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Significant methodological deficiencies no data on purity, study documentation incomplete, no data on GLP
Data source
Reference
- Reference Type:
- publication
- Title:
- Experimentelle Untersuchungen der allergenen Wirkung von Ortho- und Paranitrochlorbenzol
- Author:
- Rusakov, N.V. et al.
- Year:
- 1 973
- Bibliographic source:
- Gig. Sanit. No. 3, 13-16 (1973)
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Rats were exposed via inhalation to o-chloronitrobenzene for 5 months.
Vanier and Praustnitz-Küstner method
Test material
- Reference substance name:
- 1-chloro-2-nitrobenzene
- EC Number:
- 201-854-9
- EC Name:
- 1-chloro-2-nitrobenzene
- Cas Number:
- 88-73-3
- Molecular formula:
- C6H4ClNO2
- IUPAC Name:
- 1-chloro-2-nitrobenzene
- Details on test material:
- - Name of test material (as cited in study report): Ortho-nitrochlorbenzol
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Test system
- Route of induction exposure:
- inhalation
- Route of challenge exposure:
- other: Vanier and Praustnitz-Küstner method
- Vehicle:
- other: Vanier and Praustnitz-Küstner method
- Concentration:
- 0, 0,008 mg/m3
- No. of animals per dose:
- 25
- Challenge controls:
- no data
- Positive control substance(s):
- none
Results and discussion
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
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