1-chloro-2-nitrobenzene

Endpoint summary

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion

Endpoint conclusion:

adverse effect observed (sensitising)

Additional information:

In a acceptable, well documented publication which meets basic scientific principles the skin sensitisation potential of 1 -chloro-2 -nitrobenzene was investigated. The study was performed in guinea pigs with 3 drops of a 10% solution to a clipped area of the skin. On the 22nd day Freund-adjuvans was injected with the test substance into the hind paw (0.5 mg/kg bw). 28 days after the first administration 3 drops of the 10 % solution were applied to an untreated clipped area of the skin. The test substance induce sensitisation reactions in 50% of the tested animals. There is evidence that 1 -chloro-2 -nitrobenzene has a sensitisation potential (Rusakov et al., 1973).

A further indicator to a sensitisation potential of 1 -chloro-2 –nitrobenzene is the comparable chemical structure to the typical sensitizer 2,4-dinitrochlorobenzene. The allergenic activity of o-chloronitrobenzene is less marked than that of p-chloronitrobenzene; 2,4 -dinitrochlorobenzene provokes even stronger sensitisation effects than p-chloronitrobenzene.

Migrated from Short description of key information:
o-chloronitrobenzene was found to be a sensitizer

Justification for classification or non-classification

Classification:

DSD: Xi, R43. May cause sensitisation by skin contact.

EU-GHS: Skin Sensitisation Category. May cause allergic skin reaction.