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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)
Additional information:

In a acceptable, well documented publication which meets basic scientific principles the skin sensitisation potential of 1 -chloro-2 -nitrobenzene was investigated. The study was performed in guinea pigs with 3 drops of a 10% solution to a clipped area of the skin. On the 22nd day Freund-adjuvans was injected with the test substance into the hind paw (0.5 mg/kg bw). 28 days after the first administration 3 drops of the 10 % solution were applied to an untreated clipped area of the skin. The test substance induce sensitisation reactions in 50% of the tested animals. There is evidence that 1 -chloro-2 -nitrobenzene has a sensitisation potential (Rusakov et al., 1973).

A further indicator to a sensitisation potential of 1 -chloro-2 –nitrobenzene is the comparable chemical structure to the typical sensitizer 2,4-dinitrochlorobenzene. The allergenic activity of o-chloronitrobenzene is less marked than that of p-chloronitrobenzene; 2,4 -dinitrochlorobenzene provokes even stronger sensitisation effects than p-chloronitrobenzene.

Migrated from Short description of key information:
o-chloronitrobenzene was found to be a sensitizer

Justification for classification or non-classification


DSD: Xi, R43. May cause sensitisation by skin contact.

EU-GHS: Skin Sensitisation Category. May cause allergic skin reaction.