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Registration Dossier
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EC number: 201-854-9 | CAS number: 88-73-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1991
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP - Guideline study
Data source
Referenceopen allclose all
- Title:
- No information
- Author:
- Horstman, M.G. et al.: The Toxicologist 11, 87 (1991) |(abstr.)
- Title:
- No information
- Author:
- NTP, Technical Report Series No. 33, NIH Publication|93-3382, July/1993
- Title:
- No information
- Author:
- Travlos G.S. et al., Fundam. Appl. Toxicol. 30, 75-92 (1996)
Materials and methods
- GLP compliance:
- yes
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- - Name of test material (as cited in study report): 1-chloro-2-nitrobenzene
- Analytical purity: 99 %
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: F344/N
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Duration of treatment / exposure:
- 13 w
- Frequency of treatment:
- 6 h/d, 5 d/w
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 1.1, 2.3, 4.5, 9 or 18 ppm (approx. 0, 7, 14.7, 28.8, 57.6, 115.2 mg/m³)
Basis:
- Control animals:
- yes
- Details on study design:
- Post-exposure period: no
Results and discussion
Effect levels
- Dose descriptor:
- LOAEC
- Effect level:
- ca. 1.1 ppm
- Sex:
- male/female
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
clinical signs:
no clear signs of toxicity (no other information),
no deaths, no differences in body weight gain or terminal
body weight compared to controls;
haematology, male and female:
concentration-related increase in methaemoglobinaemia (m
sign: from 1.1 ppm at d23; from 2.3 ppm at all time points
with max of 1.14 g/dl at 18 ppm; f sign.: from 1.1 ppm at
week 13 and from 2.3 ppm at all time points with max of 1.04
g/dl at 18 ppm), reticulocyte count (sign. at all dose
groups at week 13), nucleated erythrocytes, leucocyte count
(predominantly at the highest dose groups of male and
females); concentration-related decrease in haematocrit,
haemoglobin, RBC (m. sign.: 1.1 ppm(d23), 4.4 ppm
(week13), 9 ppm (d4,week13),18 ppm (at all time points); f.
sign.: at every dose group at week13), MCH and MCHC (only in
females)
clinical chemistry, male and female:
increase in serum activities of sorbitol dehydrogenase and
alanine aminotransferase in different male and female
exposure groups at various time points, decrease in alkaline
phosphatase
pathology: dark spleen (1 female, 2 males, 18 ppm)
concentration-related increases in liver, spleen and right
kidney weight
Histopathologic changes:
liver: basophilia of centrilobular hepatocytes, kidney:
pigmentation and regeneration of the proximal convoluted
tubules, spleenic congestion was observed in all exposed and
control rats: in males with dose-dependent increase in
severity and in females with dose-dependent increase in
incidences; nose: hyperplasia of the nasal cavity
respiratory epithelium
Applicant's summary and conclusion
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