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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
other: published data
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Justification for type of information:
Dodecylbenzene sulfonic acids (CAS# 27176-87-0 , EC Number; 248-289-4) ) is a very close analogue of Sodium dodecylbenzenesulfonate (CAS No. 25155-30-0, EC Number; 246-680-4) ) and the dissociated acid it readily dissociates in water and release the dodecylbenzene sulfonic anion in solution.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Draize Test 1965
Principles of method if other than guideline:
The test material was applied as submitted to the intact skin and covered with a "1 x 1" gauze patch held in place with saran wrap. At the end of 4 hours, the coverings were removed and the area examined for skin irritation and corrosion. Examinations were repeated at 24 and 48 hours and scored according to Draize 1965.
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Dodecylbenzenesulphonic acid
EC Number:
248-289-4
EC Name:
Dodecylbenzenesulphonic acid
Cas Number:
27176-87-0
Molecular formula:
C18H30O3S
IUPAC Name:
Dodecylbenzenesulfonic acid
Test material form:
liquid
Details on test material:
- Name of test material (as cited in study report):Benzene sulfonic acid dodecyl- (27176-87-0).
Dodecylbenzene sulfonic acids (CAS# 27176-87-0 , EC Number; 248-289-4) ) is a very close analogue of Sodium dodecylbenzenesulfonate (CAS No. 25155-30-0, EC Number; 246-680-4) ) and the dissociated acid it readily dissociates in water and release the dodecylbenzene sulfonic anion in solution.

Test animals

Species:
rabbit
Strain:
New Zealand White
Details on test animals or test system and environmental conditions:
Male and female white New Zealand rabbits weight between 4 and 5.6 kg each. Animals were marked with a 5 digit number and held in steel cages. They were acclimated for 14 days prior to testing. Standard rabbit diet and water was provided ad libitum. Room temperature was held at 20 degrees C +/- 1 degree C, humidity at 60 +/- 5%, with a 12/12 hour light/dark cycle.

Test system

Type of coverage:
semiocclusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
0.5 mL
Duration of treatment / exposure:
4 hours
Observation period:
Observations were made after 4, 24, and 48 hours,
Number of animals:
6 (3 male, 3 female)
Details on study design:
The test material was applied as submitted to the intact skin and covered with a "1 x 1" gauze patch held in place with saran wrap. At the end of 4 hours, the coverings were removed and the area examined for skin irritation and corrosion. Examinations were repeated at 24 and 48 hours and scored according to Draize 1965.

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
primary dermal irritation index (PDII)
Basis:
mean
Time point:
other: 4 hours
Score:
3.4
Reversibility:
not reversible
Remarks on result:
other: highly irritating
Irritation parameter:
primary dermal irritation index (PDII)
Basis:
mean
Time point:
other: 24 hours
Score:
6.3
Reversibility:
not reversible
Irritation parameter:
primary dermal irritation index (PDII)
Basis:
mean
Time point:
other: 48 hours
Score:
7
Reversibility:
not reversible

Applicant's summary and conclusion

Interpretation of results:
Category 1C (corrosive) based on GHS criteria
Conclusions:
Result: corrosive
EC Classification: irritating at 0.5 mL
Executive summary:

The test material was applied as submitted to the intact skin and covered with a "1 x 1" gauze patch held in place with saran wrap. At the end of 4 hours, the coverings were removed and the area examined for skin irritation and corrosion. Examinations were repeated at 24 and 48 hours and scored according to Draize 1965 The primary dermal irritation scores were 3.4, 6.3, and 7.0 at 4, 24, and 48 hours, respectively.

The test substance is considered corrosive to skin according to OECD GHS guidelines.

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