Sodium dodecylbenzenesulfonate

Acute Toxicity: other routes

Administrative data

Endpoint:

acute toxicity: other routes

Type of information:

other: published data

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1949

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Mice in groups of 10 were given intravenous injections of C10 or C12 LAS.

GLP compliance:

not specified

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

C12 LAS

IUPAC Name:

C12 LAS

Test material form:

solid: compact

Details on test material:

- Name of test material (as cited in study report):C12 LAS homologue; C10 LAS homologue

Test animals

Species:

mouse

Strain:

other: albino, Harlan strain

Sex:

not specified

Administration / exposure

Route of administration:

intravenous

Vehicle:

not specified

Doses:

105 mg, 115 mg

Control animals:

yes

Details on study design:

The toxicological properties of several surface-active agents have been investigated. It has been demonstrated that acute toxicity by vein and by mouth are unrelated. Neither are acute and subacute oral toxicity related quantitatively. Blood pressure effects have not been found to be important factors in intravenous toxicity.

Results and discussion

Effect levels

Effect levels 1

Sex:

not specified

Dose descriptor:

LD50

Effect level:

105 mg/kg bw

Based on:

test mat.

Remarks:

C12 LAS

Effect levels 2

Sex:

not specified

Dose descriptor:

LD50

Effect level:

115 mg/kg bw

Based on:

test mat.

Remarks:

C10 LAS

Applicant's summary and conclusion

Conclusions:

The LD50 value of 105 mg/kg (C12 LAS) and 115 mg/kg (C10 LAS) was determined in this study by intravenous route of administration.

Executive summary:

The LD50 value of 105 mg/kg (C12 LAS) and 115 mg/kg (C10 LAS) wasdetermined in this study by intravenous route of administration.The toxicological properties of several surface-active agents have been investigated. It has been demonstrated that acute toxicity by vein and by mouth are unrelated. Neither are acute and subacute oral toxicity related quantitatively. Blood pressure effects have not been found to be important factors in intravenous toxicity.