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EC number: 246-680-4 | CAS number: 25155-30-0
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- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
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- Short-term toxicity to aquatic invertebrates
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Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to soil macroorganisms except arthropods: long-term
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- QSAR prediction: US EPA accepted QSAR method for chemicals properties assessment.
- Qualifier:
- according to guideline
- Guideline:
- other: QSAR
- Principles of method if other than guideline:
- ECOSAR Program (v1.00)
- GLP compliance:
- no
- Remarks:
- not applicable to QSAR models
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- other: earthworm
- Animal group:
- other: QSAR model
- Study type:
- other: QSAR
- Substrate type:
- other: QSAR
- Limit test:
- no
- Total exposure duration:
- 14 d
- Test temperature:
- not applicable. QSAR model
- pH:
- not applicable. QSAR model
- Moisture:
- not applicable. QSAR model
- Details on test conditions:
- 100% Benzenesulfonic acid, dodecyl-, sodium salt
SMILES : O([Na])S(=O)(=O)c1ccc(cc1)CCCCCCCCCCCC
CHEM : Benzenesulfonic acid, dodecyl-, sodium salt
CAS Num: 25155-30-0
MOL FOR: C18 H29 O3 S1 Na1
MOL WT : 348.48
Log Kow: 3.00 (KowWin estimate)
Wat Sol: 800 mg/L (experimental database) - Reference substance (positive control):
- no
- Duration:
- 14 d
- Dose descriptor:
- LC50
- Effect conc.:
- 477.471 mg/kg soil ww
- Nominal / measured:
- not specified
- Conc. based on:
- not specified
- Basis for effect:
- not specified
- Remarks on result:
- other: 1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
- Details on results:
- LC50 (14-day, earthworm)= 477.471 mg/L (ppm)
1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
LC50 (14-day, earthworm)=477.471 mg/kg soil dw - Reported statistics and error estimates:
- US EPA accepted QSAR method for chemicals properties assessment.
- Validity criteria fulfilled:
- yes
- Remarks:
- US EPA accepted QSAR method for chemicals properties assessment.
- Conclusions:
- LC50 (14-day, earthworm)= 477.471 mg/L (ppm)
1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
LC50 (14-day, earthworm)=477.471 mg/kg soil dw - Executive summary:
The ECOSAR QSAR model predicts that 14-day, LC50 (14-day, earthworm) would to be 477.471 mg/L (ppm).
1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
LC50 (14-day, earthworm)=477.471 mg/kg soil dw
- Endpoint:
- toxicity to soil macroorganisms except arthropods: long-term
- Type of information:
- other: published data
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 207 (Earthworm, Acute Toxicity Tests)
- Principles of method if other than guideline:
- OECD Guideline 207, 1984. Ten adult worms (mean wt. 0.66 g/animal) were placed into each of four glass jars per concentration with soil comprised of 70% 5010 grade silica sand, 20% kaolinite clay, and 10% finely ground sphagnum peat. Nominal test concentrations in the soil were 1000, 500, 250, 125, 63 and 0 mg/kg dry weight. Temperature was maintained at 20+/-2oCwith 24-hour continuous lighting at 600 lux. Earthworms were assessed for mortality, general health, body weight, and behavior after 7 and 14 days.
- GLP compliance:
- not specified
- Analytical monitoring:
- yes
- Vehicle:
- yes
- Test organisms (species):
- Eisenia fetida
- Animal group:
- annelids
- Details on test organisms:
- Species :Earthworm (Eisenia foetida), mean weight 660 mg
No. of worms: 10 worms/jar, 4 jars/treatment. - Study type:
- laboratory study
- Substrate type:
- artificial soil
- Limit test:
- no
- Total exposure duration:
- 14 d
- Post exposure observation period:
- Earthworms were assessed for mortality, general health, body weight and behavior after 7 and 14 days.
- Test temperature:
- 20±2℃
- Moisture:
- 35±1%.
- Details on test conditions:
- - Soil : 70% silica sand, 20% kaolinite clay and 10% sphagnum peat- Soil Temperature: 20 +/- 2 deg C- Soil moisture : 35%- Lamp: cool white fluorescence lamps, 700-750 lux (24 hours)
- Nominal and measured concentrations:
- norminally 1000, 500, 250, 125, 63, and 1 microgram/gram dry weight
- Duration:
- 14 d
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 000 mg/kg soil dw
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks:
- Mortality, Weight
- Remarks on result:
- other: Eisenia foetida / LAS : 14days-LC50 > 1mg/g. (nominal).
- Duration:
- 14 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 250 mg/kg soil dw
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks:
- Mortality, Weight
- Details on results:
- All group had 100% wurvival except the 1000 mg/kg which had 95% survival. A 33% and 23 % reduction in body weight was pbserved at 100 and 500 mg/kg. Based on statistical analysis of the weight data, the no effect concentration was nominal 250 mg/kg dose, which was confirmed by HPLC to be 235 mg/kg.
- Validity criteria fulfilled:
- yes
- Conclusions:
- All group had 100% wurvival except the 1000 mg/kg which had 95% survival. A 33% and 23 % reduction in body weight was pbserved at 100 and 500 mg/kg. Based on statistical analysis of the weight data, the no effect concentration was nominal 250 mg/kg dose, which was confirmed by HPLC to be 235 mg/kg.
The 14d-LC50for Eisenia foetida was more than 1000 mg/kg. - Executive summary:
An earthworm acute toxicity test (OECD TG 207) of commercial LAS (average carbon chain length of 11.36) was performed with Eisenia foetida on artificial soil. The 14d-LC50for Eisenia foetida was more than 1000 mg/kg.
- Endpoint:
- toxicity to soil macroorganisms except arthropods: long-term
- Type of information:
- other: published data
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- according to guideline
- Guideline:
- other: other guideline: US Food and Drug Administration guidelines No. 4.12 ‘Earthworm Subacute Toxicity’
- Principles of method if other than guideline:
- Ten adult earthworms (mean wt. 3.2 g/animal) were placed in each of four replicate one-gallon glass jars for each test concentration. Nominal test concentrations in the soil were 1333, 667, 333, 167, 84, and 0 mg/kg dry weight. Soil was comprised of 70% silica sand, 20% kaolinite clay, and 10% sphagnum peat. Rabbit faeces was added as food at 50 g/kg. Temperature was maintained at 13+/-2oC with 24 hour continuous lighting at 700-750 lux. Worms were assessed fo mortality, general health, body weight, and behavior after 7 and 14 days.
- GLP compliance:
- not specified
- Analytical monitoring:
- not specified
- Test organisms (species):
- other: Lumbricus terrestris
- Animal group:
- annelids
- Details on test organisms:
- - Test animal : adult, initial mean weight 3.2 g
Lumbricus terrestris (soil dwelling worm) - Study type:
- laboratory study
- Substrate type:
- artificial soil
- Limit test:
- no
- Total exposure duration:
- 14 d
- Post exposure observation period:
- Earthworms were assessed for mortality, general health, body weight and behavior after 7 and 14 days.
- Test temperature:
- 13 +/- 2 deg C
- Moisture:
- 20-29%
- Details on test conditions:
- - Soil : 70% silica sand, 20% kaolinite clay and 10% sphagnum peat- Soil Temperature: 13 +/- 2 deg C- Soil moisture : 20-29%
- Nominal and measured concentrations:
- narminally 1333, 667, 333, 167, 84 and 1 microgram/gram dry weight
- Duration:
- 14 d
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 333 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks:
- Mortality, Weight
- Remarks on result:
- other: Lumbricus terrestris /LAS : 14days-LC50 is 1.33mg/g(nominal).
- Duration:
- 14 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 667 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Details on results:
- 14 day LC50 > 1333 mg/kg. Motality varied from 0 to 22.5 % but there were no statistically significant differences among treatment groups. Based on weight and burrowing behavior, the no effect concentration was nominal 667 mg/kg dose, measureded HPLC 613 mg/kg.
- Validity criteria fulfilled:
- yes
- Conclusions:
- 14 day LC50 > 1333mg/kg. Motality varied from 0 to 22.5 % but there were no statistically significant differences among treatment groups. Based on weight and burrowing behavior, the no effect concentration was nominal 667 μg/g dose, measureded HPLC 613 mg/kg.
- Executive summary:
In this study 14d-LC50value was more than 1,333 mg/kg for Lumbricus terrestris.
No statistically significant mortality was observed at the highest nominal concentration of 1333 mg/kg. Based on weight and burrowing behavior, the no effect concentration was the nominal 667 mg/kg dose, which was confirmed by HPLC to be 613 mg/kg. It should be noted that the continuous lighting prevented normal feeding, which normally occurs at night on the surface, and thus the test conditions and results should be considered highly conservative.
Referenceopen allclose all
Overview of QSARs estimations on toxicity of
Sodium dodecylbenzenesulfonate/Benzenesulfonic acid, dodecyl-, sodium salt
to soil macroorganisms
Method
|
Results |
Remarks |
Reference |
QSAR estimate |
LC50 (14-day, earthworm)= 477.471 mg/L (ppm)
|
Reliable withrestrictions, QSAR estimated data |
ECOSAR Program (v1.00) |
LC50 (14-day, earthworm)= 477.471 mg/kg soil dw
Measured concentration was 94% of nominal.
Parameter
|
Time (d) |
Nominal concentration [mg/kg soil] |
|||||
0 |
63 |
125 |
250 |
500 |
1000 |
||
Mortality [%] |
14 |
0 |
0 |
0 |
0 |
0 |
5 |
Description of key information
An earthworm acute toxicity test (OECD TG 207) of commercial LAS (average carbon chain length of 11.36) was performed with Eisenia foetida on artificial soil. The 14d-LC50 for Eisenia foetida was more than 1000 mg/kg. The No effect concentration was nominal NOEC=250 mg/kg soil.
In another study used Lumbricus terrestris for 14days and 14d-LC50 value was more than 1333 mg/kg. The no effect concentration was nominal NOEC=667 mg/kg soil.
Key value for chemical safety assessment
- Short-term EC50 or LC50 for soil macroorganisms:
- 1 000 mg/kg soil dw
- Long-term EC10, LC10 or NOEC for soil macroorganisms:
- 250 mg/kg soil dw
Additional information
An earthworm acute toxicity test (OECD TG 207) of commercial LAS (average carbon chain length of 11.36) was performed with Eisenia foetida on artificial soil. The 14d-LC50 for Eisenia foetida was more than 1000 mg/kg.
The No effect concentration was nominal NOEC=250 mg/kg soil.
In another study used Lumbricus terrestris for 14 days and 14d-LC50 value was more than 1333 mg/kg. The no effect concentration was nominal NOEC=667 mg/kg soil.
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