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Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
other: Human observational study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978

Materials and methods

Study type:
study with volunteers
Endpoint addressed:
acute toxicity: dermal
skin irritation / corrosion
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Method:0.04, 0.4, and 4% aqueous solutions of LAS were applied in 48-h closed-patch tests on the lower backs of 20 women with hand eczema and 42 with other skin diseases. The skin reaction was scored grossly from 0 to 5 on the basis of the occurrence or intensity of erythema, papules, and vesicles.
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
C12-LAS
IUPAC Name:
C12-LAS
Details on test material:
C12-LAS

Method

Type of population:
general
Subjects:
20 women with hand eczema and 42 with other skin diseases.
Ethical approval:
confirmed, but no further information available
Route of exposure:
dermal
Reason of exposure:
intentional
Exposure assessment:
measured
Details on exposure:
In order to assess the possible etiological correlation between exposure to LAS and hand eczema, 0.04, 0.4, and 4% aqueous solutions of LAS were applied in 48-h closed-patch tests on the lower backs of 20 women with hand eczema and 42 with other skin diseases.
Examinations:
The skin reaction was scored grossly from 0 to 5 on the basis of the occurrence or intensity of erythema, papules, and vesicles.

Results and discussion

Results of examinations:
The skin reaction was scored grossly from 0 to 5 on the basis of the occurrence or intensity of erythema, papules, and vesicles.
The average score appeared to increase in parallel with the concentration of LAS but did not differ between the groups with hand eczema and other skin diseases

Applicant's summary and conclusion

Conclusions:
The skin reaction was scored grossly from 0 to 5 on the basis of the occurrence or intensity of erythema, papules, and vesicles.
The average score appeared to increase in parallel with the concentration of LAS but did not differ between the groups with hand eczema and other skin diseases .Solutions ofLAS do not induce hand eczema in humans.