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EC number: 701-068-0
CAS number: 2156592-58-2
24 h after challange (removing the patch), erythema grade 1 was recorded
for 2 out of 10 test animals. After 48 and 72 h, no further signs of
irritation were observed. The maximum percentage of animals sensitized
In a GLP-compliant OECD TG 406 skin sensitization study according
to Magnusson-Kligmann (guinea pig - maximisation test, GPMT), 10 female
guinea pigs + 5 control animals (strain Dunkin-Hartley) were treated
with coco alkylamine ("Genamin CC 100 D", technical grade, purity 99.9%,
liquid) using cotton seed oils as a vehicle. Based on the results of a
pretest, a test substance concentration of 0.1% was used for intradermal
induction (0.1 mL), followed by a 1% concentration at epidermal
induction. Challenge was performed using a 0.5% substance concentration.
For epidermal treatments, patches were loaded with 0.5 mL. In contrast
to results of the pretest, no dermal irritation was observed after
epidermal induction. After challenge treatment, 2/10 animals showed
grade 1 erythema at the 24h reading (positive rate = 20%). One out of
these positive animals showed scaling after 48 and 72h. Considering the
reported data of this sensitization test it can be stated that the test
item Coco alkyl amines caused slight reactions at the tested
concentration in 2 out of 10 animals identified as sensitization.
However, according to the EC criteria Coco alkyl amine does not classify
as skin sensitizer as the sensitization rate was 20%.
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