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EC number: 701-068-0
CAS number: 2156592-58-2
With regard to mutagenicity, only negative results were obtained for
primary alkylamines in both, in vitro and in vivo. C12 -18 -(even
numbered)-alkylamines have been shown to be not mutagenic in bacterial
gene mutation testing. Likewise only negative results from tests on
bacterial mutagenicity and data on gene and chromosome mutations in
mammalian cells in vitro and on chromosomal aberrations and micronuclei
in vivo were revealed for the whole category of primary alkylamines.
Alltogether, the negative data are considered as sufficient to exclude a
mutagenic potential of C12 -18 -(even numbered)-alkylamines in vivo.
This conclusion is in line with the existing EU risk assessment on
primary alkylamines in general.
Based on the available database confirming the absence of a mutagenic
potential in vitro as well as in vivo, respective classification of C12
-18 -(even numbered)-alkylamines, as well as of the whole category of
primary alkylamines, is not warranted.
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