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EC number: 701-068-0
CAS number: 2156592-58-2
In an GLP
compliant OECD TG 405 study, 100 mg the test substance Farmin TH
(hydrogenated tallow alkyl amine), a white solid (pH = 9.93, purity
95%), was applied to the eyes of three New Zealand White rabbits.
Pronounced conjunctiva redness and chemosis was observed throughout the
entire observation period. Additionally, severe cornea opacity and
moderate iris lesions was noted. Mean Draize scores for conjunctiva
redness at 24, 48 and 72 hours were 3.0, 3.0 and 3.0. Mean scores for
conjunctiva chemosis were 3.0, 3.0 and 3.3 for the same time points.
These effects were not reversible within the observation period of 21
days. Related scores for iris were 1.0, 1.0 and 1.0, reversible between
14 and 21 days. Scores for cornea density were 3.0, 3.3 and 3.7,
respectively and showed a value of 2.0 at the end of the observation
period. Based on the findings of this study, the test material Farmin TH
is considered to be severely irritating to eyes.
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