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EC number: 701-068-0
CAS number: 2156592-58-2
In an OECD TG 401 study, the test material Armeen C, a clear
light-yellow, oily liquid, was orally applied to Wistar rats at doses of
500, 1000, 1500 and 2000 mg/kg bw. The substance was applied as a 20%
solution in peanut oil (pH 8.1). At 500 mg/kg bw, two males died 5 and 7
days after treatment, respectively. At 1000 mg/kg bw, two males and two
females died between days 5-14 (40%). At 1500 mg/kg bw, four males and
four females and at 2000 mg/kg bw (80%), ten males and nine females died
between days 5-14 (95%). An LD50 of 1300 mg/kg bw (1240 mg for male and
1390 mg for female rats) was calculated (probit analysis after Finney).
Clinical signs, observed in all treatment groups, included apathia,
slight to pronounced irregular postures, uncoordinated movements,
reduced reflexes, cyanosis, salivation, piloerection, slightly reduced
breathing rate and some cases of slight hypothermia. Symptoms started
from 20 minutes after dosing on and were present until death or up to 7
days in survivors. After dissection of dead animals, slight reddening
and liquid congregations were detected in the gastrointestinal tract.
There were no pathological findings in the surviving animals.
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