Amines, C12-18-(even numbered) and C18-(unsaturated) alkyl

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1975

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Study is available only as abstract

Data source

Reference

Reference Type:

secondary source

Title:

Unnamed

Year:

1975

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Deviations:

yes

Remarks:

1 hour LC50 determined

GLP compliance:

not specified

Test type:

other: 1 hour LC50 according to standard protocol

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Coco Alkylamines

IUPAC Name:

Coco Alkylamines

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male

Administration / exposure

Route of administration:

inhalation: aerosol

Type of inhalation exposure:

whole body

Vehicle:

air

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

1 h

Concentrations:

Mean analytical concentrations of 0.063 and 0.099 mg/L

No. of animals per sex per dose:

10

Control animals:

no

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LC50

Effect level:

> 0.099 mg/L air

Based on:

test mat.

Exp. duration:

1 h

Mortality:

No

Clinical signs:

other: Hypoactivity, mild to severe irritation around the muzzle, nasal discharge

Body weight:

Not affected

Gross pathology:

Yes, no findings

Applicant's summary and conclusion

Interpretation of results:

other: No indication of strong toxic potential when tested at non-corrosive concentration

Remarks:

Criteria used for interpretation of results: expert judgment

Conclusions:

The 1 hour LC 50 was found to exceed 0.099 mg/L in male rats. The symptomatology did not indicate a strong toxic potential when tested at a non-corrosive concentration.

Executive summary:

In a range finding study groups of ten male Sprague-Dawley rats were exposed to a vapour of coco alkylamines (“Armeen C”) at mean analytical concentrations of 0.063 and 0.099 mg/l for one hour by whole-body exposure. Chamber concentrations were monitored during the entire one-hour exposure period at a rate of 0.52 l/min. Rats were observed for mortality and signs of toxicity and/or abnormal behaviour throughout the exposure and daily for 14 days after the termination of exposure. Body weights were recorded prior to exposure and on day 14. All surviving rats were subjected to a gross necropsy, and the following tissues excised and preserved in 10% neutral buffer formalin: brain, liver, kidney, heart, pancreas, stomach, lungs, spleen and testes. The tissues from the animals in the 0.099 mg/l group were examined under a light microscope. There were no deaths, accordingly, the one hour LC50 was found to exceed 0.099 mg/l. After five minutes of exposure several rats in the 0.063 mg/l dose group were preening and inactive. All animals were hypoactive after ten minutes. After 40 minutes, several animals exhibited a slight irritation around the muzzle. This latter effect, as well as hypoactivity in all rats, continued for the remainder of the exposure period. After ten minutes of exposure all rats in the 0.099 mg/l dose group were hypoactive. After 30 minutes, several animals showed signs of irritation, were preening, and exhibited a nasal discharge. At the end of the one-hour exposure, all rats showed mild to severe irritation around the muzzle and had reddish areas of discoloration on the fur. All rats in both groups exhibited normal appearance and behaviour throughout the 14-day postexposure observation period. A mean body weight gain in both dose groups was noted at the end of the observation period. No necropsy findings were noted in any rats from both dose groups.