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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

In a GLP compliant OECD TG 404 study, 0.5 ml C12-18-(even numbered)-alkylamines (Genamin CC 100 D) were semi-occlusively applied to the shaved skin of six New Zealand White rabbits for 3 and 60 minutes (three animals / exposure). Both treatments caused moderate to severe erythema and oedema. Eschar, scabbing and necroses were observed up to 14 days and subsequent scaring was noted up to the end of the observation period of 21 days.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

There are no human data on acute toxicity for C12 -18 -(even numbered)-alkylamines nor for any of the other primary alkylamines considered a chemical category with respect to chemical safety assessment. In animals, data from all primary alkylamines demonstrated a significant dermal irritative potential of this chemical category. C12 -18 -(even numbered)-alkylamines as well as tallow alkylamines and octadecenylamines were shown to be corrosive to rabbit skin, and, in consequence, not tested in rabbit eye. Hydrogenated tallow alkylamines and octadecylamines induced less severe effects in skin but caused severe eye irritation up to irreversible damage in the rabbit eye. For C12 -18 -(even numbered)-alkylamines, rat inhalation studies indicated irritative properties on the respiratory tract.

Effects on skin irritation/corrosion: corrosive

Effects on eye irritation: highly irritating

Effects on respiratory irritation: irritating

Justification for classification or non-classification

C12 -18 -(even numbered)-alkylamines fulfill the requirements for classification as Corrosive with the designation R35 - causes severe burns. Additionally, based on data from inhalation studies classification as Xi, R37 - irritating to respiratory system is indicated. Based on the dermal corrosive properties no testing for eye irritation was performed.