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EC number: 701-068-0
CAS number: 2156592-58-2
A bone marrow micronucleus test (OECD TG 474)
with tallow alkylamines (Genamin TA 100) in 50 Sprague Dawley rats (25
male and 25 female) led to a negative result after a single oral dose of
2000 mg/kg bw (Instituto di Ricerche Biomediche (2000c).
The test substance was applicated in sesame oil by intragastric gavage.
Sampling times were 24 h and 48 h after treatment. The tested dose
induced clinical signs of toxicity (piloerection, hunched posture,
hypoactivity and shallow breathing) in all animals. One male rat of the
48 h sampling time group died. For the mutagenicity evaluation 2000
polychromatic erythrocytes per animal were counted and scored for
micronucleated cells. On the basis of the results obtained there was no
significant difference between the micronucleus frequency in the treated
groups in comparison with the negative control group, at any sampling
time. The group of animals treated with Cyclophosphamide showed
statistically significant frequency of micronucleated cells in
comparison to the control group. Furthermore the ratio of polychromatic
to normochromatic erythrocytes in both male and female animals remained
unaffected by the tretament indicating that the test article is not
toxic to bone marrow cells. Thus it is concluded that under the
conditions of the present study Genamin TA 100 is not mutagenic in the
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