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EC number: 701-068-0
CAS number: 2156592-58-2
Table 1: Cumulative Mortality [%] in the test vessels with
Number of fish
Cumulativ Mortality (%) after
Table 2: Concentrations and Recovery Rates of (Z)-Octadec-9-enylamine in
the test medium
Nominal test item conc.
Meas. conc. [mg/L]after 0 h (new medium)
Meas. conc. [mg/L]after 48 h (old medium
Meas. conc. [mg/L]after 48 h (new medium)
Meas. conc. [mg/L]after 96 h (old medium
< detection limit
The acute toxicity of the test item (Z)-Octadec-9-enylamine (batch no.
89) to fish (Zebrafish) was determined according to the principles of
OECD 203 / EC Commission Directive 92/69/C.1 from 2006-03-06 to
2006-03-10 at DR.U.NOACK-LABORATORIEN, Sarstedt, Germany. A semistatic
test in natural river water with one renewal of the test media after 48
h was conducted with the following nominal concentrations: 1.00 - 1.78 -
3.16 - 5.62 - 10.0 mg/L. Duration of the test was 96 h. 7 test organisms
were exposed to each test concentration and control. Water quality
parameters temperature, pH-value, O2-saturation measured at 0, 24, 48,
72 and 96 h were determined to be within the acceptable limits. All
concentration levels were analytically verified via LC-MS/MS. Freshly
prepared test media at sampling time 0 and 48 h and corresponding 48 h
old solutions were analysed. The measured initial concentrations of both
series were in good accordance except the highest tested concentration
where deviations were found. In 48 h old media the test item
concentrations had decreased but were still detectable. Adsorption to
the test vessels after 48 h of exposure, determined from the dosage
levels framing the LC50, was in the range of 2 – 14 % (for details of
the analytical method and results please refer to chapter 9). The test
item has a low water solubility and sorbs to organic and inorganic
materials by different mechanisms. The sorption processes are mostly
non-linear, means are concentration dependent. Due to these properties
the test item is difficult to test in synthetic water (e.g. sorption to
the test organism and walls of the test vessel) and results from such
tests depend from the test settings applied. Using natural river water
which contains particulate as well as dissolved organic carbon to which
the test item can sorb partially reduces the difficulties encountered in
tests with synthetic water e.g. preventing that the test item settles
onto surfaces. The sorbed fraction of the test item is difficult to
extract from the test system which normally leads to low analytical
recoveries. Due to the short exposure period these low recoveries cannot
be associated to biodegradation. This means the test substance is
present in the test system and therefore available for exposure
(dissolved in water and sorbed also called bulk). Due to the properties
of the test item nominal concentrations have to be used instead of
measured ones (see Table 1). This so called Bulk Approach is described
by ECETOC (2003). Sorption of the test item to the glass ware of the
test system was monitored and found to be small.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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