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EC number: 701-068-0
CAS number: 2156592-58-2
GLP-compliant study similar to OECD TG 402, the test compound Amine KK
(cocoalkylamine), a yellow liquid (purity 100%), was dermally applied
under occlusion to Sprague-Dawley rats. At a dose level of 500 mg/kg
body weight, the test material was applied undiluted (application volume
0.63 ml/kg bw), at a dose level of 2000 mg/kg bw the substance was
diluted to a 40% solution (w/v) in distilled water (application volume 5
ml/kg). Compared to a regular OECD TG 402 study a reduced number of
animals was used (4 instead of 5 animals/dose). There were no
mortalities, hence, the LD50 is > 2000 mg/kg bw. No clinical signs were
observed at 500 mg/kg bw. At 2000 mg/kg, hunched posture, abnormal gait,
lethargy and decreased respiratory rate were noted. Signs of dermal
reactions at the application site of both treatments were well defined
to moderate oedema until days 4-5. Hard scabs, persisting to the end of
the observation period, frequently prevented the assessment of oedema
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