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EC number: 701-068-0
CAS number: 2156592-58-2
Mutagenicity of octadecenylamine (ODA-FG-11
-27 -84) at the hprt locus was investigated in Chinese hamster ovary
cells at concentrations of 0.1 to 2.0 nl/ml without S-9 mix and of 5.0
to 10 nl/ml with S-9 mix. No relevant cytotoxicity (decrease in cloning
efficiency) was found for the analysed concentrations; without S-9 mix
concentrations higher than 2.0 nl/ml led to strong cytotoxicity so that
cloning was not successful. In general, there was no increase in
mutation frequencies after treatment, with the exception of the highest
concentrations of 2.0 nl/ml (without S-9 mix) and 9.0 nl/ml (with S-9
mix) in the first experiment. Since no genetic effects were seen at
lower concentrations and the second experiments were clearly negative
with and without S-9 mix, these increased mutation frequencies can be
interpreted as outliers (due to the low statistical power of this test
system). Altogether, the test result is negative.
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