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EC number: 200-843-6
CAS number: 75-15-0
Comparing with the control group, the levels
of Cyt C, Smac, IAPS, Caspase-3, Bax, and Bax/Bcl-2 mRNA in the sertoli
germ cells were increased, while the levels of Apaf-1, Alf, Bcl-2, and
EndoG mRNA were decreased in CS2 exposure groups (P < 0.05).
The effects on carbon disulfide (CS2) on the expression
of genes which are related with mitochondrion mediated sertoli-germ cells
apoptosis were studied in male rats. A 22 -24 day old SD male rat of clean
grade was selected to establish the rat sertoli-germ cells co-culture system
in vitro. According to the designed concentrations of CS2 (0, 1, 2, 4 µmol/mL),
the cells were divided into four groups accordingly and RNA were extracted.
The mRNA expression levels of Cyt C, Apaf-1, Caspase-3, Caspase-9, Alf, EndoG,
Smac, IAPS, Bax, Bcl-2 were detected by real-time fluorescent quantitative
polymerase chain reaction (RT-PCR). Comparing with the control group, the
levels of Cyt C, Smac, IAPS, Caspase-3, Bax, and Bax/Bcl-2 mRNA in the sertoli
germ cells were increased, while the levels of Apaf-1, Alf, Bcl-2, and EndoG
mRNA were decreased in CS2 exposure groups (P<0.05). In conclusion, CS2
exposure affects the expression of genes related with mitochondrial mediated
apoptosis, and it propably relates to reproductive toxicity induced by CS2.
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