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EC number: 200-843-6
CAS number: 75-15-0
disulphide was examined for its mutagenic activity in four
histidine-dependent auxotrophs ofSalmonella typhimurium, strains
TA98, TA100, TA1535, TA1537. Agar plates, seeded with the tester
strains, were exposed to the test material in vapour phase, in the
abscence and presence of metabolic activation, in the following nominal
concentrations: 0.005%, 0.01%, 0.025%, 0.05% and 0.1% v/v (nominal).
These concentrations were selected following preliminary toxicity tests
in strain TA 98. Carbon disulphide did not exhibit any
mutagenic activity under the conditions of this test. No increases in
revertants were obtained in any of the four tester strains following
exposure to carbon disulphide at the concentrations tested. Inhibition
of bacterial growth, observed as thinning of the background lawn of
non-revertant cells and reduction in revertant colony numbers, occurred
in all strains with carbon disulphide at a nominal concentration of 0.1%v/v.
The positive and negative controls were valid.
was performed according to the OECD Guidelines for Testing of Chemicals
No. 471 (1983) and US EPA (TSCA) Guideline §
798.5265 (1985, amended 1987).
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