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EC number: 200-843-6
CAS number: 75-15-0
Two groups, each consisting of three female
RccHan:WIST (SPF) rats, were treated with Carbon disulfide by single
oral gavage administration at a dosage of 2000 mg/kg body weight. The
test item was formulated in corn oil at a concentration of 0.2 g/mL and
administered at a dosing volume of 10 mL/kg. The animals were examined
daily during the acclimatization period and mortality, viability and
clinical signs were recorded. All animals were examined for clinical
signs immediately before treatment, within the first 30 minutes and
approximately 1, 2, 3 and 5 hours after treatment on day 1 and once
daily during test days 2-15. Mortality/viability was recorded
immediately before treatment, within the first 30 minutes and
approximately 1, 2, 3 and 5 hours after administration on test day 1
(with the clinical signs) and twice daily during days 2-15. Body weights
were recorded on day 1 (prior to administration) and on days 8 and 15.
All animals were necropsied and examined macroscopically. No
intercurrent deaths occurred during the course of the study. Slightly
ruffled fur was observed in all animals on test day 1 and in one animal
also on test day 2. The body weight of the animals was within the range
commonly recorded for this strain and age.
No macroscopic findings were recorded at
necropsy. The median lethal dose of Carbon disulfide after single oral
administration to female rats, observed over a period of 14 days, is:
LD50 (female rat): greater than 2000 mg/kg body weight.
Based upon the referred classification
criteria (Regulation (EC) No 1272/2008 of the European Parliament and of
the Council of 16 December 2008), carbon disulfide is not classified
with respect to acute oral toxicity in the rat.
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