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EC number: 200-843-6
CAS number: 75-15-0
Through 2007 the mortality experience of
1874 workers employed at a New York chemical manufacturing plant between
1946 and 2006 was updated. For the update a company-provided electronic
work history database (complete as to April 2006) was merged with the
exisiting NIOSH database. In addition to documented exposures to
o-toluidine, aniline, and nitrobenzene, exposures at the plant included
vinyl chloride, carbon disulfide and rotating shift work. Coronary
artery disease was investigated as the outcome of interest for carbon
disulfide. As many workers exposed to carbon disulfide also performed
shift work, the risk of coronary artery disease mortality in groups
defined by duration of exposure to these agents were evaluated. Internal
comparisons showed increased coronary artery disease mortality among
long-term workers exposed to carbon disulfide and shift work for 4 years
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