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EC number: 200-843-6
CAS number: 75-15-0
SPECIAL NEUROPATHOLOGICAL EXAMINATIONS:
axonal swelling of the muscular nerve in all 5 animals exposed to the
high concentration, as well as of the sural nerve in all males and 3/5
females (Table 1, attachment). One female rat exposed to the 2nd
concentration exhibited a similar lesion in a single fiber of the sural
nerve. Axonal swelling was observed in the muscular and sural nerves, as
well as in the lumbar and cervical cord fibers in both sexes exposed to
subchronic inhalation toxicity study, carbon disulfide was administered
to male and female Fischer 344 rats as vapour by inhalation at the
following nominal concentrations: 0, 50, 300, and 800 ppm (analytical:
0, 153.7, 925.9, and 2488.3 mg/m3-49.3, 297.1, 798.4 ppm), for 6
hours/day, 5 days/week for at least 89 consecutive days. No mortality
was observed among the animals during the experiment. No substance
related clinical signs were observed except for ataxia (highest
concentration). Depression in body weights was seen in males at 300 and
800 ppm and only at 800 ppm in females. Some hematological changes and
clinical changes were measured, mainly at 800 ppm. The elevated
transaminases in the serum indicate liver damage, although no histologic
lesions were noted. The increase in urea nitrogen was probably related
to reduced water consumption, as suggested by the diminished urine
volumes and elevated urine specific gravity. Calcium changes might be
associated with the histologic lesions that were observed in the
kidneys. The histopathological
examinations revealed axonal swelling of nerve fibers of the spinal
cord, and the muscular and sural nerve at 800 ppm for both sexes, as
well as segmental degeneration of fibers in the sciatic nerve in few
animals of the high dose group, and positive iron pigmentation in both
sexes exposed to 800 ppm. The study yielded a NOAEC of 50 ppm for males
(only a slight reduction in absolute brain weight but not in relative
brain weight), and of 300 ppm for females for the same reason.
subchronic inhalation toxicity study in the Fischer 344 rats is similar
to the guideline requirement for a subchronic inhalation study OECD 413.
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