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EC number: 200-843-6
CAS number: 75-15-0
Carbon disulfide (CS2), was evaluated for
teratogenic effects in timed-pregnant CD rats. The following doses were
administered: 0, 100, 200, 400 and 600 mg/kg/day in corn oil by gavage,
in a volume of 5 ml/kg bw, on gestational days (gd) 6 to 15. All animals
were sacrificed on gestation day 20. The gravid uterus for each dam was
weighed and the number of implantation sites, and live, dead or resorbed
fetuses were recorded. All live fetuses were weighed and examined for
external, visceral and skeletal malformations. For the dose groups of
200, 400 and 600 mg/kg bw/day, a significant decrease in absolute
maternal body weight gain was observed during treatment. Gravid uterine
weights showed a dose-consistent decreasing trend; still, not
significant. Larger relative liver weights were measured in the two high
dose groups. Fetal body weights were decreased in rats exposed to 200
mg/kg bw/day and above.
There was no compound-related increase in
malformations of the offspring.
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