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EC number: 200-843-6
CAS number: 75-15-0
acetone/olive oil (4:1 v/v)
Test item concentration % (w/v)
number of lymph nodes
DPM per lymph nodeb)
BG = background ( 1 mL 5% trichloroacetic
acid) in duplicate
1 = control group
2 -4 = test groups
SI = Stimulation Index
a) the mean value was taken from BG I and BG
b) since the lymph nodes of the animals of
groups 1 -4 were pooled, DPM/node was determined by dividing the
measured value by the number of lymph nodes pooled
deaths occurred during the study period.
symptoms of local toxicity at the ears of the animals and no systemic
findings were observed during the study period.
body weight of the animals, recorded prior to the first application and
prior to treatment with 3HTdR, was within the range commonly recorded
for animals of this strain and age.
this study carbon disulfide dissolved in acetone/olive oil (4:1 v/v) was
assessed for its possible contact allergenic potential. For this purpose
a local lymph node assay according to OECD guideline 429 was performed
using test item concentrations of 25, 50, and 100%. All treated animals
survived the scheduled study period and no signs of systemic toxicity or
local irritation were observed. A
test item is regarded as a sensitiser in the LLNA if the exposure to one
or more test concentration results in a 3-fold or greater increase in
incorporation of ³HTdR compared with concurrent controls, as indicated
by the Stimulation Index (S.I.). The estimated concentration of test
item required to produce a S.I. of 3 is referred to as the EC3 value. In
this study Stimulation Indices of 1.22, 0.99, and 3.46 were determined
with the test item at concentrations of 25, 50, and 100% in
acetone/olive oil (4:1). Based on the outcome at 100%, carbon disulfide
could be considered a skin sensitizer under the test conditions of this
study. However, as the lymph nodes were pooled there is no
information on the presence of outliers. Moreover, pure chemical and
thus no vehicle was used which may also have influenced the outcome. In
the opinion of the applicant this is a false positive result and CS2
cannot be considered as a skin sensitizer based on this study.
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