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EC number: 200-843-6
CAS number: 75-15-0
The effect of carbon disulphide on
chromosome structure in the bone marrow erythrocytes of mice was
examined. The animals (males and females) were exposed via inhalation
snout-only, for 6 h to the following concentrations: 0, 467, 1558, 4675
mg/m3 (0, 150, 500, 1500 ppm). The exposure concentrations were based on
a preliminary toxicity test. Chlorambucil (30 mg/kg bw) was used as a
positive control, adminstered via the oral route. Animals were
sacrifised and examined 24 and 48 h after exposure. No evidence of
induced chromosomal or other damage leading to the formation of
micronuclei in erythrocytes of the bone marrow was detected, uder the
present test condition, after exposure of the animals to CS2 via
inhalation. Mice exposed at 1500 ppm, however, showed a small increase
in the ratio of polychromatic/mature cells, which may indicate
disturbance of erythropoiesis.
Carbon disulphide was tested for induction
of micronuclei in the bone marrow ertythrocytes of mice according to the
OECD Guidelines 474 (1983).
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