Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

Currently viewing:

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: only one dose, individual animal data not shown, exposure period: 1 hour

Data source

Reference
Reference Type:
publication
Title:
Bio-Fax data sheet: o-cresol
Author:
Industrial Bio-Test Laboratories Inc.
Year:
1969
Bibliographic source:
Data sheet no 4-5/69, Industrial Bio-Test Laboratories Inc. Northbrook, Ill, USA

Materials and methods

Principles of method if other than guideline:
Method: room temperature, total air flow: 10.0 lpm (no further information) observation for clinical signs and mortality, gross autopsy.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
o-cresol
EC Number:
202-423-8
EC Name:
o-cresol
Cas Number:
95-48-7
Molecular formula:
C7H8O
IUPAC Name:
o-cresol
Details on test material:
IUCLID4 Test substance: other TS: o-cresol, no data on purity, MP 30°C

Test animals

Species:
rat
Strain:
not specified
Sex:
male
Details on test animals or test system and environmental conditions:
no further data

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
other: air
Details on inhalation exposure:
no further data
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
1 h
Concentrations:
1.22 mg/l
No. of animals per sex per dose:
6 male rabbits
Control animals:
not specified
Details on study design:
no further data
Statistics:
no data

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LC50
Effect level:
> 1.22 mg/L air
Exp. duration:
1 h
Remarks on result:
other: no mortality; generelized inactivity, lacrimation; onset: 15-30 minutes; recovery at treatment day
Mortality:
no
Clinical signs:
other: generelized inactivity, lacrimation; onset: 15-30 minutes; recovery at treatment day
Body weight:
initial mean body weight: 197 g;
terminal mean body weight: 250 g.
Gross pathology:
no significant findings
Other findings:
no further details

Any other information on results incl. tables

no further details

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Executive summary:

Exposure of male rats to the test substance for 1 hour amd post-exposure observation for clinical signs anf mortality resulted in no mortality: but generalized inactivity: LC50 >1.22 mg/L/1h air (Industrial Biotest Laboratories 1969).