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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: only one dose, individual animal data not shown, exposure period: 1 hour

Data source

Reference
Reference Type:
publication
Title:
Bio-Fax data sheet: o-cresol
Author:
Industrial Bio-Test Laboratories Inc.
Year:
1969
Bibliographic source:
Data sheet no 4-5/69, Industrial Bio-Test Laboratories Inc. Northbrook, Ill, USA

Materials and methods

Principles of method if other than guideline:
Method: room temperature, total air flow: 10.0 lpm (no further information) observation for clinical signs and mortality, gross autopsy.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
o-cresol
EC Number:
202-423-8
EC Name:
o-cresol
Cas Number:
95-48-7
Molecular formula:
C7H8O
IUPAC Name:
o-cresol
Details on test material:
IUCLID4 Test substance: other TS: o-cresol, no data on purity, MP 30°C

Test animals

Species:
rat
Strain:
not specified
Sex:
male
Details on test animals or test system and environmental conditions:
no further data

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
other: air
Details on inhalation exposure:
no further data
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
1 h
Concentrations:
1.22 mg/l
No. of animals per sex per dose:
6 male rabbits
Control animals:
not specified
Details on study design:
no further data
Statistics:
no data

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LC50
Effect level:
> 1.22 mg/L air
Exp. duration:
1 h
Remarks on result:
other: no mortality; generelized inactivity, lacrimation; onset: 15-30 minutes; recovery at treatment day
Mortality:
no
Clinical signs:
other: generelized inactivity, lacrimation; onset: 15-30 minutes; recovery at treatment day
Body weight:
initial mean body weight: 197 g;
terminal mean body weight: 250 g.
Gross pathology:
no significant findings
Other findings:
no further details

Any other information on results incl. tables

no further details

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Executive summary:

Exposure of male rats to the test substance for 1 hour amd post-exposure observation for clinical signs anf mortality resulted in no mortality: but generalized inactivity: LC50 >1.22 mg/L/1h air (Industrial Biotest Laboratories 1969).

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