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EC number: 202-423-8 | CAS number: 95-48-7
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Principles of method if other than guideline:
- Light absorbance measurements combined with electrometric measurements of pH
- GLP compliance:
- not specified
- Dissociating properties:
- yes
- No.:
- #1
- pKa:
- 10.29
- Temp.:
- 25 °C
- Conclusions:
- The pKa of o-cresol was determined based on light absorbance measurements combined with electrometric measurements of pH at 25°C. A pKa of 10.29 was obtained.
- Executive summary:
The pKa of o-cresol is 10.29 at 25°C.
Reference
Description of key information
The dissociation constant (pKa) of o-cresol is 10.29 at 25°C.
Key value for chemical safety assessment
- pKa at 20°C:
- 10.29
Additional information
There is only a value at 25°C available. It is assumed that change in pKa is not a very sensitive function of temperature, and the value at 25°C is therefore assigned to a temperature of 20°C.
o-Cresol is a weak acid. The pKa value of 10.29 indicates that at environmentally relevant pH values (5 - 9) the substance is largely non-dissociated.
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