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Dissociation constant

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Reference
Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Principles of method if other than guideline:
Light absorbance measurements combined with electrometric measurements of pH
GLP compliance:
not specified
Dissociating properties:
yes
No.:
#1
pKa:
10.29
Temp.:
25 °C
Conclusions:
The pKa of o-cresol was determined based on light absorbance measurements combined with electrometric measurements of pH at 25°C. A pKa of 10.29 was obtained.
Executive summary:

The pKa of o-cresol is 10.29 at 25°C.

Description of key information

The dissociation constant (pKa) of o-cresol is 10.29 at 25°C.

Key value for chemical safety assessment

pKa at 20°C:
10.29

Additional information

There is only a value at 25°C available. It is assumed that change in pKa is not a very sensitive function of temperature, and the value at 25°C is therefore assigned to a temperature of 20°C.

o-Cresol is a weak acid. The pKa value of 10.29 indicates that at environmentally relevant pH values (5 - 9) the substance is largely non-dissociated.