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Toxicological information

Repeated dose toxicity: dermal

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Administrative data

Endpoint:
repeated dose toxicity: dermal
Remarks:
other: in vivo
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: individual animal data not shown

Data source

Reference
Title:
No information
Author:
Shelley WB (1974). p-Cresol: Cause of ink-induced hair depigmentation in mice. Br. J. Dermatol. 90, 169-174

Materials and methods

Principles of method if other than guideline:
4Method: other: application to clipped or epilated area of the back, 3 times weekly for 4 weeks.
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
Automatically generated during migration to IUCLID 6, no data available
IUPAC Name:
Automatically generated during migration to IUCLID 6, no data available
Details on test material:
IUCLID4 Test substance: other TS: ocresol, no data on purity

Test animals

Species:
mouse
Strain:
other: CBA/J agouti
Sex:
female

Administration / exposure

Type of coverage:
not specified
Vehicle:
acetone
Details on exposure:
Route of Administration: dermal
Duration of treatment / exposure:
4 w
Frequency of treatment:
3/w
Doses / concentrations
Remarks:
Doses / Concentrations:
0.5 % in acetone (= ca. 5000 mg/l), no further information
Basis:

No. of animals per sex per dose:
5
Control animals:
yes
Details on study design:
Post-exposure period: 24 w

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

RS-Freetext:
no colour change of the new hair growth

Applicant's summary and conclusion

Executive summary:

Applicaation of o-cresol to the skin of mice caused no colour change of the fur

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