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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: documentation sufficient for assessment

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Studies in detoxication. I. the influence of (a) dose and (b) o-m- and p-stubstitution on the suphate detoxication of phenol in rabbits
Author:
Williams BT
Year:
1938
Bibliographic source:
Biochem. J. 32, 878-887
Reference Type:
review article or handbook
Title:
EHC (Environmental Health Criteria) No. 168: Cresols
Author:
WHO
Year:
1995
Bibliographic source:
IPCS (International Programme on Chemical Safety) WHO, Geneva

Materials and methods

Objective of study:
metabolism
Principles of method if other than guideline:
Oral application by gavage to rabbits and urine was collected over 6 days and analysed vor total and inorganic sulphate by gravimetirc method of Folin et al (1932).
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
o-cresol
EC Number:
202-423-8
EC Name:
o-cresol
Cas Number:
95-48-7
Molecular formula:
C7H8O
IUPAC Name:
o-cresol
Details on test material:
Test substance: o-cresol, no data on purity

Test animals

Species:
rabbit
Strain:
not specified
Sex:
female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: approximately 2 kg
- Housing: singly
- Individual metabolism cages: yes
- Diet "mixed diet": 100 g cabbage , 50 g bran:
- Water ad libitum
- Acclimation period: no data


ENVIRONMENTAL CONDITIONS
- Temperature (°F):50-60

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Details on exposure:
no details given
Duration and frequency of treatment / exposure:
6 day(s)
Doses / concentrations
Remarks:
Doses / Concentrations:
Females: 290 mg/kg bw/day as aequous solution
No. of animals per sex per dose / concentration:
no data
Control animals:
not specified
Positive control reference chemical:
no data
Details on study design:
Oral application by gavage to rabbits and urine was collected over 6 days and analysed for total and inorganic sulphate by gravimetirc method of Folin et al (1932) every second day.
Details on dosing and sampling:
The urine was collected in a beaker placed at the orifice of the funnels which were changed every second day for cleaning.
Statistics:
no data

Results and discussion

Preliminary studies:
no data

Toxicokinetic / pharmacokinetic studies

Details on absorption:
no data
Details on distribution in tissues:
no data
Details on excretion:
A mean of 22 % of the applied dose was as conjugate with sulphate.

Metabolite characterisation studies

Metabolites identified:
no
Details on metabolites:
A mean of 22 % of the applied dose was as conjugate with sulphate (no further information).

Any other information on results incl. tables

22 % of the administered dose is excreted conjugated with sulphate.

Applicant's summary and conclusion

Executive summary:

Approximately 22 % of the administered o-cresol conjugated with sulfate was detected in the urinary excretion rate after oral application of 290 mg/kg bw o-cresol by gavage to female rabbits.