Registration Dossier
Registration Dossier
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EC number: 202-423-8 | CAS number: 95-48-7
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Remarks:
- in vivo study
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: documentation insufficient for assessment: only special aspects were examined
Data source
Reference
- Title:
- No information
- Author:
- Pereyma V.YA (1977). Vrach. Delo 5, 126-130
Materials and methods
- Principles of method if other than guideline:
- Method: see section "any other information on material and methods".
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- o-cresol
- EC Number:
- 202-423-8
- EC Name:
- o-cresol
- Cas Number:
- 95-48-7
- Molecular formula:
- C7H8O
- IUPAC Name:
- o-cresol
- Details on test material:
- o-cresol, no data on purity
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- air
- Remarks on MMAD:
- MMAD / GSD: no data
- Details on inhalation exposure:
- see section:"Any other information on material and methods".
- Analytical verification of doses or concentrations:
- not specified
- Details on analytical verification of doses or concentrations:
- no data
- Duration of treatment / exposure:
- 40 d
- Frequency of treatment:
- 4 h/d, daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.01 mg/l
Basis:
- No. of animals per sex per dose:
- no data
- Control animals:
- yes
- Details on study design:
- Post-exposure period: 20 d
- Positive control:
- no data
Examinations
- Observations and examinations performed and frequency:
- Concentration in the lung during exposure and post exposure.
- Sacrifice and pathology:
- no data
- Other examinations:
- Concentration in the lung during exposure and post exposure.
Results and discussion
Results of examinations
- Clinical signs:
- not specified
- Mortality:
- not specified
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Histopathological findings: non-neoplastic:
- not specified
- Histopathological findings: neoplastic:
- not specified
- Details on results:
- see section "Remarks on results"
Effect levels
- Dose descriptor:
- conc. level:
- Effect level:
- 0.01 mg/L air
- Sex:
- female
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Up to d 39 of the experiment increasing amounts of o-cresol (16,4 mg/g tissue) in lung homogenates, during recovery period o-cresol decreased (d 12: 1,1 mg/g tissue), d 16 : discovery of aminophenols)
Applicant's summary and conclusion
- Executive summary:
Inhalation exposure to o-cresol leads to increasing amounts in the lung of rats which decrease during recovery period.
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