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Toxicological information

Repeated dose toxicity: inhalation

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Administrative data

Endpoint:
short-term repeated dose toxicity: inhalation
Remarks:
in vivo study
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: documentation insufficient for assessment: only special aspects were examined

Data source

Reference
Title:
No information
Author:
Pereyma V.YA (1977). Vrach. Delo 5, 126-130

Materials and methods

Principles of method if other than guideline:
Method: see section "any other information on material and methods".
GLP compliance:
not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
o-cresol
EC Number:
202-423-8
EC Name:
o-cresol
Cas Number:
95-48-7
Molecular formula:
C7H8O
IUPAC Name:
o-cresol
Details on test material:
o-cresol, no data on purity

Test animals

Species:
rat
Strain:
not specified
Sex:
female
Details on test animals or test system and environmental conditions:
no data

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
air
Remarks on MMAD:
MMAD / GSD: no data
Details on inhalation exposure:
see section:"Any other information on material and methods".
Analytical verification of doses or concentrations:
not specified
Details on analytical verification of doses or concentrations:
no data
Duration of treatment / exposure:
40 d
Frequency of treatment:
4 h/d, daily
Doses / concentrations
Remarks:
Doses / Concentrations:
0.01 mg/l
Basis:

No. of animals per sex per dose:
no data
Control animals:
yes
Details on study design:
Post-exposure period: 20 d
Positive control:
no data

Examinations

Observations and examinations performed and frequency:
Concentration in the lung during exposure and post exposure.
Sacrifice and pathology:
no data
Other examinations:
Concentration in the lung during exposure and post exposure.

Results and discussion

Results of examinations

Clinical signs:
not specified
Mortality:
not specified
Body weight and weight changes:
not specified
Food consumption and compound intake (if feeding study):
not specified
Food efficiency:
not specified
Water consumption and compound intake (if drinking water study):
not specified
Ophthalmological findings:
not specified
Haematological findings:
not specified
Clinical biochemistry findings:
not specified
Urinalysis findings:
not specified
Behaviour (functional findings):
not specified
Organ weight findings including organ / body weight ratios:
not specified
Histopathological findings: non-neoplastic:
not specified
Histopathological findings: neoplastic:
not specified
Details on results:
see section "Remarks on results"

Effect levels

Dose descriptor:
conc. level:
Effect level:
0.01 mg/L air
Sex:
female

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

Up to d 39 of the experiment increasing amounts of o-cresol (16,4 mg/g tissue) in lung homogenates, during recovery period o-cresol decreased (d 12: 1,1 mg/g tissue), d 16 : discovery of aminophenols)

Applicant's summary and conclusion

Executive summary:

Inhalation exposure to o-cresol leads to increasing amounts in the lung of rats which decrease during recovery period.