Registration Dossier
Registration Dossier
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EC number: 202-423-8 | CAS number: 95-48-7
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: individual animal data not shown
Data source
Reference
- Title:
- No information
- Author:
- Shelley WB (1974). p-Cresol: Cause of ink-induced hair depigmentation in mice. Br. J. Dermatol. 90, 169-174
Materials and methods
- Principles of method if other than guideline:
- Application to clipped or epilated area of the back, 3 times weekly for 4 weeks.
- GLP compliance:
- no
Test material
- Reference substance name:
- o-cresol
- EC Number:
- 202-423-8
- EC Name:
- o-cresol
- Cas Number:
- 95-48-7
- Molecular formula:
- C7H8O
- IUPAC Name:
- o-cresol
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: CBA/J agouti
- Sex:
- female
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- acetone
- Details on exposure:
- Route of Administration: dermal
- Duration of treatment / exposure:
- 4 w
- Frequency of treatment:
- 3/w
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.5 % in acetone (= ca. 5000 mg/l), no further information
Basis:
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- Post-exposure period: 24 w
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
No colour change of the new hair growth.
Applicant's summary and conclusion
- Executive summary:
Application of o-cresol to the skin of mice caused no colour change of the fur.
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