Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: patients with contact allergy were used

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Contact allergy to o-cresol - a sensitizer in phenol-formaldehyde resin.
Author:
Bruze M and E Zimerson
Year:
2002
Bibliographic source:
Am. J. Contact Dermatitis 13, 196-200
Reference Type:
publication
Title:
Cross-reaction patterns in patients with contact allergy to simple methylol phenols
Author:
Bruze M, Zimerson E
Year:
1997
Bibliographic source:
Contact Dermatitis 37, 82-86

Materials and methods

Type of sensitisation studied:
skin
Study type:
other: patients with contact allergy
Principles of method if other than guideline:
Patch testing with patients.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
o-cresol
EC Number:
202-423-8
EC Name:
o-cresol
Cas Number:
95-48-7
Molecular formula:
C7H8O
IUPAC Name:
o-cresol
Details on test material:
IUCLID4 Test substance: other TS: o-cresol, purity was confirmed by analytical HPLC, data not given

Method

Type of population:
other: patients with contact allergy
Ethical approval:
not specified
Subjects:
4 patients exposed (no further data)
Clinical history:
no data
Controls:
20 healthy persons
Route of administration:
dermal
Details on study design:
no data

Results and discussion

Results of examinations:
no patient reacted to 0.81 mmol/l
3/4 reacted positive to 8.1 mmol/l
4/4 patients reacted positive to 81 mmol/l
no control person reacted to the test

Any other information on results incl. tables

no further data

Applicant's summary and conclusion

Executive summary:

Patients suffering from contact alllergy were tested with o-cresol and revealed positive reactions.