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Description of key information

There is no study according to the current OECD test guideline but the studies, which were choses as key studies, are adequately documented and are considered of sufficient quality to allow  an evaluation of this endpoint. Based on the results in these studies o-cresol is evaluated as corrosive

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

There is no study according to the current OECD test guideline but the studies, which were choses as key studies, are adequately documented and are considered of sufficient quality to allow an evaluation of this endpoint.

SKIN

Undiluted o-cresol was applied to the intact and abraded skin of rabbits (no further experimental details given) and caused within 24 hours severe erythema and edema in each rabbit (mean score 8.00 of 8.00 [max], Ind. Bio-test Lab Inc 1969). In another study, application of o-cresol for 4 hours under semiocclusive conditions yielded severe edema and necrosis within 24 hours and eschar formation within 14 days (no scores given, Ferro Corp 1978).

EYE

Application of o-cresol into the conjunctival sac of the rabbits eyes resulted in severe irritation (mean score: 91.3 of 110[max]). Recovery was not reported (Ind. Bio-test Lab Inc 1969).

OVERALL

Based on the results in these studies o-cresol is evaluated as corrosive


Effects on skin irritation/corrosion: corrosive

Effects on eye irritation: corrosive

Effect level: empty Endpoint conclusion: Adverse effect observed

Justification for classification or non-classification

Under R67/548/EEC(19.ATP) m-and p-cresol as well as o-cresol are classified as corrosive R34 = causes burns

According to Regulation (EC) No. 1272/2008 the substance is allocated to category 1B of skin corrosive substances; Hazard Classification H314

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