Registration Dossier
Registration Dossier
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EC number: 202-423-8 | CAS number: 95-48-7
Immunotoxicity
Administrative data
- Endpoint:
- immunotoxicity
- Remarks:
- other: in vivo study over 14 days
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: only summary available
Data source
Reference
- Title:
- No information
- Author:
- Chemical Industrial Institute of Toxicology (CIIT, 1983). Preliminary result of in-vivo and in-vitro Sister Chromatid Exchange Assay on cresol isomers and of an immunological evaluation of o-cresol. CIIT Docket 12283,
- Bibliographic source:
- EPA-OTS0507479
Materials and methods
- Principles of method if other than guideline:
- other: see section"any other information on materials and method"
- GLP compliance:
- not specified
Test material
- Reference substance name:
- o-cresol
- EC Number:
- 202-423-8
- EC Name:
- o-cresol
- Cas Number:
- 95-48-7
- Molecular formula:
- C7H8O
- IUPAC Name:
- o-cresol
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- B6C3F1
- Sex:
- female
Administration / exposure
- Route of administration:
- other: drinking water
- Vehicle:
- water
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- Exposure period: 14 day(s)
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 6.5, 32.5, 65, 130 mg/kg bw/day
Basis:
- No. of animals per sex per dose:
- no data
- Control animals:
- yes
- Details on study design:
- Observation period: during treatment.
Results and discussion
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- ca. 130 mg/kg bw/day (actual dose received)
- Sex:
- female
- Basis for effect level:
- other: no evidence for immunotoxicity or altered host resistance
Any other information on results incl. tables
Result:
o-cresol does not induce immunotoxicity or altered host resistance in
mice after 14 days of exposure in drinking water.
Applicant's summary and conclusion
- Executive summary:
o-cresol does not induce immunotoxicity or altered host resistance in mice after 14 days of exposure in drinking water.
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