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Diss Factsheets

Administrative data

Endpoint:
immunotoxicity
Remarks:
other: in vivo study over 14 days
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: only summary available

Data source

Reference
Title:
No information
Author:
Chemical Industrial Institute of Toxicology (CIIT, 1983). Preliminary result of in-vivo and in-vitro Sister Chromatid Exchange Assay on cresol isomers and of an immunological evaluation of o-cresol. CIIT Docket 12283,
Bibliographic source:
EPA-OTS0507479

Materials and methods

Principles of method if other than guideline:
other: see section"any other information on materials and method"
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
o-cresol
EC Number:
202-423-8
EC Name:
o-cresol
Cas Number:
95-48-7
Molecular formula:
C7H8O
IUPAC Name:
o-cresol

Test animals

Species:
mouse
Strain:
B6C3F1
Sex:
female

Administration / exposure

Route of administration:
other: drinking water
Vehicle:
water
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
Exposure period: 14 day(s)
Frequency of treatment:
daily
Doses / concentrations
Remarks:
Doses / Concentrations:
0, 6.5, 32.5, 65, 130 mg/kg bw/day
Basis:

No. of animals per sex per dose:
no data
Control animals:
yes
Details on study design:
Observation period: during treatment.

Results and discussion

Effect levels

Dose descriptor:
NOAEL
Effect level:
ca. 130 mg/kg bw/day (actual dose received)
Sex:
female
Basis for effect level:
other: no evidence for immunotoxicity or altered host resistance

Any other information on results incl. tables

Result:
o-cresol does not induce immunotoxicity or altered host resistance in mice after 14 days of exposure in drinking water.

Applicant's summary and conclusion

Executive summary:

o-cresol does not induce immunotoxicity or altered host resistance in mice after 14 days of exposure in drinking water.

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