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Diss Factsheets

Administrative data

Endpoint:
cytotoxicity
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: in vitro investigation,reliability of limited significance

Data source

Reference
Title:
No information
Author:
Thompson DC et al.(1994). Cresol isomers: Comparison of toxic potency in rat liver slices. Toxicol. Appl. Pharmacol. 125, 51-58

Materials and methods

Principles of method if other than guideline:
Precision-cut slices were prepared from male Sprague-Dawley rat livers and were then treated with the different cresol isomers to detect differences in toxicity
GLP compliance:
not specified
Type of method:
in vitro

Test material

Constituent 1
Chemical structure
Reference substance name:
o-cresol
EC Number:
202-423-8
EC Name:
o-cresol
Cas Number:
95-48-7
Molecular formula:
C7H8O
IUPAC Name:
o-cresol
Details on test material:
no data on purity of o-cresol (CAS-Nr. 95-48-4)

Test animals

Species:
other: in vitro testing
Strain:
other: in vitro testing

Administration / exposure

Route of administration:
other: in vitro testing
Vehicle:
other: water or DMSO
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
incubation time not specified
Frequency of treatment:
in vitro testing
Post exposure period:
in vitro testing
No. of animals per sex per dose:
in vitro testing

Results and discussion

Any other information on results incl. tables

In rat liver slices, o-cresol was less toxic by comparison
with p-cresol. Glutathione depletion or addition of a thiol
precursor had only little effect on cytotoxicity of
o-cresol.

Applicant's summary and conclusion

Executive summary:

In rat liver slices, o-cresol was less toxic by comparison
with p-cresol. Glutathione depletion or addition of a thiol
precursor had only little effect on cytotoxicity of
o-cresol.

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