Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-423-8 | CAS number: 95-48-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: sufficient information for evaluation
Data source
Reference
- Reference Type:
- publication
- Title:
- Bio-Fax data sheet: o-cresol
- Author:
- Industrial Bio-Test Laboratories Inc.
- Year:
- 1 969
- Bibliographic source:
- Data sheet no 4-5/69, Industrial Bio-Test Laboratories Inc. Northbrook, Ill, USA
Materials and methods
- Principles of method if other than guideline:
- Application of the undiluted substance on shaved intact or abraded skin areas, coverage not mentioned, reading 24,48, 72 hours.
- GLP compliance:
- no
Test material
- Reference substance name:
- o-cresol
- EC Number:
- 202-423-8
- EC Name:
- o-cresol
- Cas Number:
- 95-48-7
- Molecular formula:
- C7H8O
- IUPAC Name:
- o-cresol
- Details on test material:
- IUCLID4 Test substance: other TS: o-cresol, no data on purity, MP 30 °C
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- no further information
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- other: shaved : intact and abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- no data
- Observation period:
- 72 hours
- Number of animals:
- 6
- Details on study design:
- Evaluation of erythema and edema.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 4
- Max. score:
- 4
- Reversibility:
- no data
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 4
- Max. score:
- 4
- Reversibility:
- no data
- Irritation parameter:
- overall irritation score
- Basis:
- other: mean value overall animals
- Time point:
- other: abraded and intacxt skin: after 72 hours
- Score:
- ca. 8
- Max. score:
- 8
- Reversibility:
- no data
- Irritant / corrosive response data:
- no further information
- Other effects:
- no further information
Any other information on results incl. tables
intact and abraded skin:
total irritation score: 8.00/8.00
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (corrosive) based on GHS criteria
- Executive summary:
Application of 0.5 ml undiluted substance on shaved intact or abraded rabbit skin areas, coverage not mentioned, and reading 24, 48, 72 hours post application yielded mean irritation score: 8 of max 8. Reversibility is not reported (Industrial Biotest Laboratories 1969).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
