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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable publication

Data source

Reference
Reference Type:
publication
Title:
The Toxicity of Butyl Cellosolve Solvent
Author:
Carpenter, C.P. et al.
Year:
1956
Bibliographic source:
Arch. Ind. Health 14, 114-131

Materials and methods

Principles of method if other than guideline:
other: Acute intravenous and intraperitoneal toxicity
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Name of the test substance as stated in the publication: "Cellosolve"

Test animals

Species:
rat
Strain:
not specified
Sex:
female

Administration / exposure

Route of administration:
other: intravenous and intraperitoneal
Vehicle:
other: NaCl solution (0.75 %) for intravenious injection
Doses:
undiluted; 0.18 % in 0.75 % NaCl

Results and discussion

Effect levelsopen allclose all
Sex:
female
Dose descriptor:
LD50
Effect level:
2.38 mL/kg bw
Based on:
test mat.
Remarks on result:
other: undiluted; range 1.92 to 2.97 mL/kg; the LD50 value is equal to 2187 mg/kg with a density of 0.919 at 25 °C
Sex:
female
Dose descriptor:
LD50
Effect level:
3 250 mg/kg bw
Remarks on result:
other: 18 % of test substance in 0.75 % NaCl; range 2480 to 4260 mg/kg
Sex:
female
Dose descriptor:
LD50
Effect level:
2.14 mL/kg bw
Remarks on result:
other: intraperitoneal; range (1.54 to 2.99 mL/kg); value corresponds to 1966 mg/kg with a density of 0.919 at 25 °C

Applicant's summary and conclusion