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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
The toxicity of butyl cellosolve solvent.
Author:
Carpenter CP, Pozzani UC, Weil CS, Nair JH, Keck GA, Smyth HF
Year:
1956
Bibliographic source:
AMA Arch. Ind. Health 14, 114-131

Materials and methods

Principles of method if other than guideline:
Method: other: 24-hour occlusive dermal application
GLP compliance:
not specified
Test type:
other: Skin penetration toxicity

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Name of the test substance as stated in the publication: "Cellosolve"

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male
Details on test animals and environmental conditions:
animal age: 3-5 months
animal weights: 2.3-3.3 kg

Administration / exposure

Type of coverage:
other: impervious sheeting
Vehicle:
not specified
Duration of exposure:
24 hours
Doses:
2.24-5.66 mL/kg as stated in publication; calculated values: 2083-5264 mg/kg

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
3.56 mL/kg bw
Remarks on result:
other: Value corresponds to 3271 mg/kg (with a density of 0.919 at 25 °C)

Any other information on results incl. tables

The administration of the test substance by inunction on the rabbit skin led to a LD50 of 16.3 mL/kg (range 13.2 -20.2 mL/kg)

Applicant's summary and conclusion

Conclusions:
The LD50 for rabbits by skin penetration with the test substance 2-ethoxyethanol has been determined to be 3.56 mL/kg. The corresponding value for an uncovered skin treatment (rubbed into skin by gentle massage) was 16.3 mL/kg.